跳转至内容
Merck
CN

H7416

Sigma-Aldrich

白介素 -6 人

IL-6, recombinant, expressed in HEK 293 cells, suitable for cell culture

别名:

IL-6

登录查看公司和协议定价


About This Item

MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.77

生物来源

human

质量水平

重组

expressed in HEK 293 cells

检测方案

≥95% (SDS-PAGE)

形式

lyophilized powder

效能

≤2.0 ng/mL ED50

质量

endotoxin tested

分子量

dimer 26-30 kDa (glycosylated)

包装

pkg of 10 μg

技术

cell culture | mammalian: suitable

杂质

≤1.00 EU/μg

UniProt登记号

储存温度

−20°C

基因信息

human ... IL6(3569)

正在寻找类似产品? 访问 产品对比指南

一般描述

The IL6 (interleukin-6) gene is mapped to human chromosome 7p15.3. All the members of IL6 family have membrane glycoprotein gp130 as a common receptor. IL6 (interleukin-6) induces B-cell differentiation and is a primary regulator of inflammation.

应用

Interleukin-6 human has been used to check its role in breast cancer metastasis. It has also been used for evaluating its role in D5HS tumor sphere formation.

生化/生理作用

IL6 regulates tumor proliferation and inhibits apoptosis. It contributes to the disease progression of coronary artery disease.
白细胞介素-6 (IL-6) 是最初在双链 RNA 刺激的细胞培养基中发现的一种多功能蛋白。IL-6 似乎直接参与了感染和损伤后发生的反应,并可能证明在调节急性期反应方面与 IL-1 和 TNF-α 同样重要。据报道,IL-6 由成纤维细胞、活化的 T 细胞、活化的单核细胞或巨噬细胞以及内皮细胞产生。作用于多种细胞,包括成纤维细胞、髓系祖细胞、T 细胞、B 细胞和肝细胞。如许多同义词所示,IL-6 诱导多种效应:浆细胞瘤生长因子 (PCT-GF)、干扰素-β-2(IFN-β 2 )、单核细胞来源的人 B 细胞生长因子、B 细胞刺激因子 (BSF-2)、肝细胞刺激因子 (HSF)、白细胞介素杂交瘤/浆细胞瘤-1 (IL-HP1)。此外,IL-6 似乎在 T 淋巴细胞增殖中与 IL-2 相互作用。IL-6 还可增强 IL-3 对多潜能造血祖细胞的增殖作用。

制备说明

Human IL-6, expressed in human 293 cells, is a glycosylated monomer with an apparent molecular mass of 26-30 kDa due to glycosylation, which is absent when this cytokine is expressed in E. coli. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

分析说明

The specific activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Generation of Prostate Tumor-initiating Cells is Associated with Elevation of Reactive Oxygen Species and IL6/STAT3 Signaling
Qu Y, et al.
Cancer Research (2013)
The pro-and anti-inflammatory properties of the cytokine interleukin-6
Scheller J, et al.
Biochimica et Biophysica Acta, 1813(5), 878-888 (2011)
Interplay between YB-1 and IL-6 promotes the metastatic phenotype in breast cancer cells
Castellana B, et al.
Oncotarget, 6(35), 38239-38239 (2015)
The human obesity gene map: the 2003 update.
Snyder E E, et al.
Obesity Research, 12(3), 369-439 (2004)
The-174 G> C interleukin-6 gene polymorphism is associated with angiographic progression of coronary artery disease over a 4-year period.
Toutouzas K, et al.
Hellenic Journal of Cardiology : HJC = Hell?nik? Kardiologik? epithe?r?s?, 58(1), 80-86 (2017)

商品

Role of growth factors in stem cell differentiation and various growth factors for your research at sigmaaldrich.com

Lipid Induced Insulin Resistance

脂肪组织中的胰岛素耐受性减少了循环游离脂肪酸的摄入,并增加了脂肪酶对储存甘油三酯的水解。了解与胰岛素耐受性相关的激素、细胞因子和脂肪因子。

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门