H7654
Hydroxyguanidine sulfate salt
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关于此项目
线性分子式:
CH5N3O · 1/2H2SO4
化学文摘社编号:
分子量:
124.11
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
228-749-0
MDL number:
InChI key
MTGDDPZRXSDPFH-UHFFFAOYSA-N
InChI
1S/2CH5N3O.H2O4S/c2*2-1(3)4-5;1-5(2,3)4/h2*5H,(H4,2,3,4);(H2,1,2,3,4)
SMILES string
NC(=N)NO.NC(=N)NO.OS(O)(=O)=O
biological source
synthetic (organic)
assay
≥98% (TLC)
form
powder
solubility
water: 25 mg/mL, clear, colorless
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
An early antitumor agent. Oxidation results in release of NO, and formation of other reactive oxygen species, including peroxynitrite and peroxyl radicals. Reacts with NO to form an adduct which is a potent and stable vasodilator.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Rémy Ricoux et al.
European journal of biochemistry, 270(1), 47-55 (2002-12-21)
Nitric oxide (NO) is a potent intra- and intercellular messenger involved in the control of vascular tone, neuronal signalling and host response to infection. In mammals, NO is synthesized by oxidation of l-arginine catalysed by hemeproteins called NO-synthases with intermediate
Alycen Pond Nigro et al.
Archives of biochemistry and biophysics, 500(1), 66-73 (2010-03-30)
Yeast cytochrome c peroxidase was used to construct a model for the reactions catalyzed by the second cycle of nitric oxide synthase. The R48A/W191F mutant introduced a binding site for N-hydroxyguanidine near the distal heme face and removed the redox
Amila Kahvedžić et al.
Journal of medicinal chemistry, 56(2), 451-459 (2012-12-21)
In this paper we report the synthesis of a new family of hydroxyguanidinium aromatic derivatives (4a-g) as potential minor groove binders and cytotoxic agents. Their DNA affinity was evaluated by thermal denaturation experiments using salmon sperm DNA. The antiproliferative effects
T Bill Cai et al.
Current topics in medicinal chemistry, 5(7), 721-736 (2005-08-17)
Nitric oxide (NO) has been implicated in a wide variety of disease states. Both inhibitors and substrates of nitric oxide synthase (NOS) could have great therapeutic potential in the treatment of these diseases. There is considerable pharmacological interest in developing
Zembowicz, A., et al.
British Journal of Pharmacology, 107, 1007-1007 (1992)
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