生物来源
synthetic (organic)
质量水平
方案
≥98% (TLC)
表单
powder
溶解性
water: 25 mg/mL, clear, colorless
储存温度
2-8°C
SMILES字符串
NC(=N)NO.NC(=N)NO.OS(O)(=O)=O
InChI
1S/2CH5N3O.H2O4S/c2*2-1(3)4-5;1-5(2,3)4/h2*5H,(H4,2,3,4);(H2,1,2,3,4)
InChI key
MTGDDPZRXSDPFH-UHFFFAOYSA-N
生化/生理作用
An early antitumor agent. Oxidation results in release of NO, and formation of other reactive oxygen species, including peroxynitrite and peroxyl radicals. Reacts with NO to form an adduct which is a potent and stable vasodilator.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
David Lefèvre-Groboillot et al.
The FEBS journal, 272(12), 3172-3183 (2005-06-16)
The binding of several alkyl- and aryl-guanidines and N-hydroxyguanidines to the oxygenase domain of inducible NO-synthase (iNOS(oxy)) was studied by UV/Vis difference spectroscopy. In a very general manner, monosubstituted guanidines exhibited affinities for iNOS(oxy) that were very close to those
Zhi-guo Zhang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 39(9), 705-710 (2004-12-21)
To search for novel antiasthmatic agents. Coupling seratrodast (SD), an antiasthmatic drug, with several different types of NO donors including oxatriazoles, N-hydroxyguanidines and furoxans; evaluating the antiasthmatic effects of coupled compounds by determining their inhibitory activity of guinea pig asthma
Daniel Mansuy et al.
Free radical biology & medicine, 37(8), 1105-1121 (2004-09-29)
Nitric oxide (NO) is a key inter- and intracellular molecule involved in the maintenance of vascular tone, neuronal signaling, and host response to infection. The biosynthesis of NO in mammals involves a two-step oxidation of L-arginine (L-Arg) to citrulline and
Patrick Slama et al.
Biochemical and biophysical research communications, 316(4), 1081-1087 (2004-03-27)
Conversion of neurotransmitter dopamine into norepinephrine is catalyzed by dopamine beta-hydroxylase (DbH). The reaction requires the presence of both molecular oxygen and a reducing cosubstrate, the assumed physiological cosubstrate being ascorbic acid. We have investigated the ability of a new
Patrick Slama et al.
Journal of inorganic biochemistry, 103(3), 455-462 (2009-01-31)
N-Aryl-N'-hydroxyguanidines are compounds that display interesting pharmacological properties but their chemical reactivity remains poorly investigated. Some of these compounds are substrates for the heme-containing enzymes nitric-oxide synthases (NOS) and act as reducing co-substrates for the copper-containing enzyme Dopamine beta-Hydroxylase (DBH)
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