biological source
synthetic (organic)
assay
≥98% (TLC)
form
powder
solubility
water: 25 mg/mL, clear, colorless
storage temp.
2-8°C
SMILES string
NC(=N)NO.NC(=N)NO.OS(O)(=O)=O
InChI
1S/2CH5N3O.H2O4S/c2*2-1(3)4-5;1-5(2,3)4/h2*5H,(H4,2,3,4);(H2,1,2,3,4)
InChI key
MTGDDPZRXSDPFH-UHFFFAOYSA-N
Biochem/physiol Actions
An early antitumor agent. Oxidation results in release of NO, and formation of other reactive oxygen species, including peroxynitrite and peroxyl radicals. Reacts with NO to form an adduct which is a potent and stable vasodilator.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
T Bill Cai et al.
Current topics in medicinal chemistry, 5(7), 721-736 (2005-08-17)
Nitric oxide (NO) has been implicated in a wide variety of disease states. Both inhibitors and substrates of nitric oxide synthase (NOS) could have great therapeutic potential in the treatment of these diseases. There is considerable pharmacological interest in developing
Kamil Brożewicz et al.
European journal of medicinal chemistry, 55, 384-394 (2012-08-16)
Twenty four 1-[2-alkylthio-5-(azol-2 or 5-yl)-4-chlorobenzenesulfonyl]-3-hydroxyguanidines 6a-x have been synthesized in order to evaluate their biological activity. Compounds 6a, 6c, 6d, 6f, 6g, 6i-p, 6r-t, and 6v-x were tested for their in vitro anticancer activity at the US National Cancer Institute. The
Zembowicz, A., et al.
British Journal of Pharmacology, 107, 1007-1007 (1992)
Amila Kahvedžić et al.
Journal of medicinal chemistry, 56(2), 451-459 (2012-12-21)
In this paper we report the synthesis of a new family of hydroxyguanidinium aromatic derivatives (4a-g) as potential minor groove binders and cytotoxic agents. Their DNA affinity was evaluated by thermal denaturation experiments using salmon sperm DNA. The antiproliferative effects
Alycen Pond Nigro et al.
Archives of biochemistry and biophysics, 500(1), 66-73 (2010-03-30)
Yeast cytochrome c peroxidase was used to construct a model for the reactions catalyzed by the second cycle of nitric oxide synthase. The R48A/W191F mutant introduced a binding site for N-hydroxyguanidine near the distal heme face and removed the redox
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| H7654-50MG | 04061832947884 |
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