H8876
5-羟基吲哚-3-乙酸
≥98% (HPLC), crystalline
别名:
5-HIAA
产品名称
5-羟基吲哚-3-乙酸, ≥98% (HPLC), crystalline
质量水平
方案
≥98% (HPLC)
表单
crystalline
颜色
white to purple
mp
161-164 °C (dec.) (lit.)
储存温度
−20°C
SMILES字符串
OC(=O)Cc1c[nH]c2ccc(O)cc12
InChI
1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14)
InChI key
DUUGKQCEGZLZNO-UHFFFAOYSA-N
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相关类别
一般描述
5-羧基吲哚-3-乙酸(5-HIAA) 是血清素途径的分解代谢终产物。5-HIAA存在于体液中，如脑脊液（CSF）、血液和尿液。正常患者和癌症患者具有不同的5-HIAA表达水平。墨蝶呤还原酶缺乏可导致脑脊液中的5-HIAA水平降低。患有儿童注意力缺陷多动障碍（ADHD）的1型双相障碍患者的脑脊液5-HIAA水平较低。
应用
5-羟基吲哚-3-乙酸已被用作通过高效液相色谱法（HPLC）测量小鼠脑组织中5-HIAA的标准品。
生化/生理作用
主要的血清素代谢产物。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Combining tissue transcriptomics and urine metabolomics for breast cancer biomarker identification
Nam H, et al.
Bioinformatics, 25(23), 3151-3157 (2009)
Lower CSF HVA and 5-HIAA in bipolar disorder type 1 with a history of childhood ADHD
Ryden E, et al.
Journal of neural transmission (Vienna, Austria : 1996), 116(12), 1667-1674 (2009)
Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression
Park HS, et al.
Oncotarget, 8(42), 72528-72543 (2017)
Progression and recovery of Parkinsonism in a chronic progressive MPTP-induction model in the marmoset without persistent molecular and cellular damage
Franke SK, et al.
Neuroscience, 312, 247-259 (2016)
Makoto Tsunoda et al.
Biomedical chromatography : BMC, 33(11), e4650-e4650 (2019-07-18)
Solid-phase extraction technologies are widely used for sample pretreatment in bioanalysis. Monolithic silica disk-packed spin columns modified with phenylboronate moieties have been developed for the selective extraction of cis-diol compounds such as catecholamines. However, in our preliminary studies, serotonin was
商品
血清素（5-羟色胺）主要存在于三种主要细胞类型中：i）中杻神经系统（CNS）和肠肌间神经丛中的血清素能神经元，ii）胃肠道粘膜中的肠嗜铬细胞，和iii）血小板。血清素的代谢主要通过外部线粒体膜酶单胺氧化酶（MAO）进行，它以两种分子亚型存在，分别称为MAO-A和MAO-B。
Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.
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