质量水平
方案
≥97%
表单
powder
溶解性
H2O: soluble
alcohol: soluble
chloroform: soluble
SMILES字符串
Cl[H].Cl[H].OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3
InChI
1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H
InChI key
ANOMHKZSQFYSBR-UHFFFAOYSA-N
基因信息
human ... HRH1(3269)
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一般描述
Hydroxyzine dihydrochloride (HDH) is the first-generation antihistamine, that belongs to the piperazine class, an H1 receptor antagonist.
应用
Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.
生化/生理作用
Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Repr. 2 - STOT SE 3
靶器官
Central nervous system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
N Javaud et al.
Annales francaises d'anesthesie et de reanimation, 30(11), 848-850 (2011-10-08)
We are reporting the case of a bradykinin-mediated angioedema, secondary to the angiotensin converting enzyme inhibitors, which delayed treatment could have unfavorably influence the vital prognostic of the patient. Initially, the patient had an isolated edema of the superior lip.
Kaori Kimura-Kuroiwa et al.
Journal of anesthesia, 26(3), 422-428 (2012-02-22)
Investigation into the characteristics of anesthetic interactions may provide clues to anesthesia mechanisms. Dexmedetomidine, an α(2)-adrenergic receptor agonist, has become a popular sedative in intensive care, and hydroxyzine, a histamine receptor antagonist, is well known as a tranquilizing premedication for
Central nervous system-impairing effects of hydroxyzine as a function of histamine availability.
Silke Conen et al.
Journal of clinical psychopharmacology, 33(2), 276-279 (2013-02-21)
Byung Hoon Lee et al.
Acta pharmacologica Sinica, 32(9), 1128-1137 (2011-09-06)
To investigate the effects of hydroxyzine on human ether-a-go-go-related gene (hERG) channels to determine the electrolphysiological basis for its proarrhythmic effects. hERG channels were expressed in Xenopus oocytes and HEK293 cells, and the effects of hydroxyzine on the channels were
Donatella Marazziti et al.
Current topics in medicinal chemistry, 12(4), 238-253 (2011-12-30)
Anxiety disorders represent the most prevalent psychiatric disorders. In addition, a considerable burden is associated with them, not only for individual sufferers, but also for the health care system. However, many patients who might benefit from treatment are not diagnosed
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