Merck
CN
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文件

H8885

Sigma-Aldrich

羟嗪 二盐酸盐

≥97%

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经验公式（希尔记法）:
C21H27ClN2O2 · 2HCl
CAS号:
2192-20-3
分子量:
447.83
EC 号:
218-586-3
MDL编号:
MFCD00058200
PubChem化学物质编号:
24895830
NACRES:
NA.77

质量水平

200

检测方案

≥97%

形式

powder

溶解性

H2O: soluble
alcohol: soluble
chloroform: soluble

SMILES字符串

Cl[H].Cl[H].OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3

InChI

1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H

InChI key

ANOMHKZSQFYSBR-UHFFFAOYSA-N

基因信息

human ... HRH1(3269)

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一般描述

Hydroxyzine dihydrochloride (HDH) is the first-generation antihistamine, that belongs to the piperazine class, an H1 receptor antagonist.

应用

Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.

生化/生理作用

Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Repr. 2 - STOT SE 3

靶器官

Central nervous system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Acid-base titrimetric assay of hydroxyzine dihydrochloride in pharmaceutical samples
Rajendraprasad N, et al.
Chemical Industry Times / Hua Gong Shi Kan, 16(2), 127-132 (2010)
COMPARATIVE ANXIOLYTIC ACTIVITY OF VARIOUS DRUGS IN EXPERIMENTAL MODELS OF RATS
Vitthal K R, et al.
International Journal of Current Research and Review, 4(24), 77-77 (2012)
Walter Ling et al.
Addiction (Abingdon, England), 107(2), 361-369 (2011-11-16)
To evaluate the efficacy and safety of the PROMETA™ Protocol for treating methamphetamine dependence. A double-blind, placebo-controlled 108-day study with random assignment to one of two study conditions: active medication with flumazenil (2 mg infusions on days 1, 2, 3
Sp Georgopoulos et al.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 17(2), 377-382 (2012-06-29)
The purpose of the current experimental research was to investigate whether hydroxyzine can reduce the necrotic area in ischemia-reperfusion injury in epigastric rat skin flaps and to compare its role with cimetidine and vitamin C. From a total of 77
A Ghanizadeh
European review for medical and pharmacological sciences, 17(6), 839-841 (2013-04-24)
Bruxism or sleep jaw clenching and grinding of the teeth is an unresolved area in dentistry, psychiatry, and medicine. While many therapeutic approaches are introduced, nearly all of them are not effective or some of them are invasive approach. Three
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Chromatograms

application for HPLC

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