H8885
羟嗪 二盐酸盐
≥97%
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关于此项目
经验公式（希尔记法）:
C21H27ClN2O2 · 2HCl
化学文摘社编号:
分子量:
447.83
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
EC Number:
218-586-3
MDL number:
InChI key
ANOMHKZSQFYSBR-UHFFFAOYSA-N
InChI
1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H
SMILES string
Cl[H].Cl[H].OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3
assay
≥97%
form
powder
solubility
H2O: soluble, alcohol: soluble, chloroform: soluble
Quality Level
Gene Information
human ... HRH1(3269)
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General description
Hydroxyzine dihydrochloride (HDH) is the first-generation antihistamine, that belongs to the piperazine class, an H1 receptor antagonist.
Application
Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.
Biochem/physiol Actions
Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2 - STOT SE 3
target_organs
Central nervous system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Acid-base titrimetric assay of hydroxyzine dihydrochloride in pharmaceutical samples
Rajendraprasad N, et al.
Chemical Industry Times / Hua Gong Shi Kan, 16(2), 127-132 (2010)
COMPARATIVE ANXIOLYTIC ACTIVITY OF VARIOUS DRUGS IN EXPERIMENTAL MODELS OF RATS
Vitthal K R, et al.
International Journal of Current Research and Review, 4(24), 77-77 (2012)
Mohammad Othman et al.
The Cochrane database of systematic reviews, 7(7), CD009223-CD009223 (2012-07-13)
Labour is a normal physiological process, but is usually associated with pain and discomfort. Numerous methods are used to relieve labour pain. These include pharmacological (e.g. epidural, opioids, inhaled analgesia) and non-pharmacological (e.g. hypnosis, acupuncture) methods of pain management. Non-opioid
A Ghanizadeh
European review for medical and pharmacological sciences, 17(6), 839-841 (2013-04-24)
Bruxism or sleep jaw clenching and grinding of the teeth is an unresolved area in dentistry, psychiatry, and medicine. While many therapeutic approaches are introduced, nearly all of them are not effective or some of them are invasive approach. Three
E Davidovich et al.
The Journal of clinical pediatric dentistry, 36(4), 389-392 (2012-10-02)
To investigate whether behavior during hydroxyzine administration predicts children's behavior during dental treatment and whether behavior during treatment is affected by the complexity of treatment. 118 children aged 2 to 6.5 years old were treated under conscious sedation with oral
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