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About This Item

MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.77
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Product Name

Vascular Endothelial Growth Factor 121 human, VEGF121, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

生物来源

human

质量水平

重组

expressed in HEK 293 cells

方案

≥95% (SDS-PAGE)

表单

lyophilized powder

效能

≤15 ng/mL EC50

质量

endotoxin tested

分子量

dimer 37 kDa (glycosylated)
trimer 50 kDa (glycosylated)

包装

pkg of 10 μg

制造商/商品名称

HumanZyme

储存条件

avoid repeated freeze/thaw cycles

技术

cell culture | mammalian: suitable

杂质

≤1 EU/μg

UniProt登记号

储存温度

−20°C

基因信息

human ... VEGFA(7422)

一般描述

HumanPro VEGF-121(vascular endothelial growth factor 121) is an isoform of VEGFA and is expressed in human HEK 293 cells as a disulfide linked, glycosylated cytokine with an apparent molecular mass of 37 kDa as a homodimer and 50 kDa as a homotrimer. VEGF-A exists in three different isoforms VEGF-121, VEGF165 is an angiogenic properties. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
There are five types of VEGF ligands identified in mammals, which exists as different splice variants.VEGFA is a dimeric glycoprotein consisting two monomers antiparallel to each other.

生化/生理作用

Vascular endothelial growth factor 121 (VEGF121) belongs to the PDGF/VEGF growth factor family. Many cell types secrete VEGF, and it is a potent angiogenic factor and mitogen that stimulates proliferation, migration, and formation of endothelial cells. VEGF stimulates permeabilization of blood vessels and is present in some tumors of the nervous system. VEGF is induced by hypoxia, oncogene mutations, and cytokines such as IL-1, IL-8, and TNF-α.

外形

Lyophilized from a 0.2 μm filtered solution of 1X PBS

分析说明

The specific activity was determined by the dose-dependent stimulation of the proliferation of HUVEC cells (human umbilical vein endothelial cells).

法律信息

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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