H9041
Vascular Endothelial Growth Factor 121 human
HumanKine®, ≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
dimer 37 kDa (glycosylated), trimer 50 kDa (glycosylated)
Impurities:
≤1 EU/μg
产品名称
Vascular Endothelial Growth Factor 121 human, VEGF121, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
biological source
human
Quality Segment
recombinant
expressed in HEK 293 cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
≤15 ng/mL EC50
quality
endotoxin tested
mol wt
dimer 37 kDa (glycosylated), trimer 50 kDa (glycosylated)
packaging
pkg of 10 μg
manufacturer/tradename
HumanZyme
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
≤1 EU/μg
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... VEGFA(7422)
General description
HumanPro VEGF-121(vascular endothelial growth factor 121) is an isoform of VEGFA and is expressed in human HEK 293 cells as a disulfide linked, glycosylated cytokine with an apparent molecular mass of 37 kDa as a homodimer and 50 kDa as a homotrimer. VEGF-A exists in three different isoforms VEGF-121, VEGF165 is an angiogenic properties. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
There are five types of VEGF ligands identified in mammals, which exists as different splice variants.VEGFA is a dimeric glycoprotein consisting two monomers antiparallel to each other.
There are five types of VEGF ligands identified in mammals, which exists as different splice variants.VEGFA is a dimeric glycoprotein consisting two monomers antiparallel to each other.
Biochem/physiol Actions
Vascular endothelial growth factor 121 (VEGF121) belongs to the PDGF/VEGF growth factor family. Many cell types secrete VEGF, and it is a potent angiogenic factor and mitogen that stimulates proliferation, migration, and formation of endothelial cells. VEGF stimulates permeabilization of blood vessels and is present in some tumors of the nervous system. VEGF is induced by hypoxia, oncogene mutations, and cytokines such as IL-1, IL-8, and TNF-α.
Physical form
Lyophilized from a 0.2 μm filtered solution of 1X PBS
Analysis Note
The specific activity was determined by the dose-dependent stimulation of the proliferation of HUVEC cells (human umbilical vein endothelial cells).
Legal Information
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Still not finding the right product?
Explore all of our products under Vascular Endothelial Growth Factor 121 human
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable