H9149
α-Hydroxyalprazolam
powder, ≥98% (TLC)
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关于此项目
经验公式（希尔记法）:
C17H13ClN4O
化学文摘社编号:
分子量:
324.76
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
InChI
1S/C17H13ClN4O/c18-12-6-7-14-13(8-12)17(11-4-2-1-3-5-11)19-9-15-20-21-16(10-23)22(14)15/h1-8,23H,9-10H2
SMILES string
OCc1nnc2CN=C(c3ccccc3)c4cc(Cl)ccc4-n12
InChI key
ZURUZYHEEMDQBU-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
drug control
Home Office Schedule 4.1; regulated under CDSA - not available from Sigma-Aldrich Canada
color
white to off-white
solubility
methylene chloride: ~20 mg/mL, clear, colorless to faintly yellow
Disclaimer
store dessicated and protected from light
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
R B Smith et al.
Psychopharmacology, 93(1), 105-112 (1987-01-01)
The relationships between alprazolam and metabolite concentrations and CNS effects were determined in a double-blind placebo controlled four-way crossover trial in 16 normal male volunteers. Active drug treatments consisted of 4-day regimens of 4 mg alprazolam PO daily as 2
V D Schmith et al.
Journal of clinical pharmacology, 31(6), 571-579 (1991-06-01)
In a double-blind, randomized, placebo-controlled study, the pharmacokinetics of alprazolam and its active metabolite, alpha-hydroxyalprazolam, were determined in 12 normal subjects and 12 dialysis patients [7 hemodialysis (HD) patients and 5 continuous ambulatory peritoneal dialysis (CAPD) patients]. Blood samples were
Annika Allqvist et al.
European journal of clinical pharmacology, 63(2), 173-179 (2007-01-04)
The antifungal drug ketoconazole (KTZ) is known as an inhibitor of, especially, the CYP3A subfamily, which catalyzes the metabolism of a large variety of drugs. Interactions between KTZ and CYP3A substrates have been reported both in vivo and in vitro.
Agneta Wennerholm et al.
European journal of clinical pharmacology, 61(2), 113-118 (2005-04-05)
(1) To determine the pharmacokinetic parameters of alprazolam and its two metabolites in plasma from healthy volunteers; (2) to identify a suitable single time point to take a plasma sample for CYP3A phenotyping. Twelve healthy Swedish volunteers received a single
D J Crouch et al.
Journal of analytical toxicology, 23(6), 479-485 (1999-10-12)
A sensitive and specific electrospray ionization high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS-MS) method has been developed for the quantitative determination of alprazolam (AL) and alpha-hydroxyalprazolam (OH-AL) in plasma. After the addition of deuterium labeled internal standards of AL and OH-AL
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