H9166
血管内皮生长因子 165 人
≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture
别名:
内皮生长因子, 血管生长因子
产品名称
血管内皮生长因子 165 人, VEGF165, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
biological source
human
recombinant
expressed in HEK 293 cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
≤5 ng/mL EC50
quality
endotoxin tested
mol wt
dimer 45 kDa (glycosylated)
packaging
pkg of 5x10 μg
pkg of 10 μg
manufacturer/tradename
HumanZyme
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
≤1 EU/μg
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... VEGFA(7422)
Analysis Note
通过对 HUVEC 细胞（人脐静脉内皮细胞）增殖的剂量依赖性刺激测定比活性。
Biochem/physiol Actions
VEGF（血管内皮生长因子）作为一种有效的血管生成因子和有丝分裂原，可刺激内皮细胞的增殖、迁移和形成。VEGF 刺激血管通透性增加，存在于神经系统的一些肿瘤中。已知 VEGFA 与 VEGFR 共受体（如硫酸乙酰肝素蛋白聚糖和神经纤毛蛋白）相互作用。VEGFA 基因突变导致血管发育缺陷。VEGF 是由缺氧、癌基因突变和细胞因子如（白细胞介素）IL-1、IL-8、TNF-α（肿瘤坏死因子 α）.
General description
血管内皮生长因子 121 (VEGF121) 属于 PDGF（血小板衍生生长因子）/VEGF 生长因子家族。VEGFA 基因定位于人类染色体 6p21.1编码蛋白是一种二聚体糖蛋白，由 两个单体相互反向平行。在哺乳动物中有五种类型的 VEGF 配体，它们作为不同的剪接变异体存在。血管内皮生长因子 165 (VEGF165) 属于 PDGF（血小板衍生生长因子）/VEGF 生长因子家族，VEGF 由许多细胞类型分泌。人 VEGF165 在人 HEK 293 细胞中以糖基化同源二聚体形式表达，表观分子量为 45 kDa。在人 HEK 293 细胞中的生产提供了真实的糖基化。糖基化有助于细胞生长培养基和其他应用中的稳定性。
Physical form
从过滤的1X PBS溶液中（经0.2 μm过滤）冻干。
Legal Information
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
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