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H9250

Sigma-Aldrich

组蛋白 来源于小牛胸腺

Type II-A, lyophilized powder

别名:

histone type VIII-S

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500 MG
¥10,747.66

¥10,747.66


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500 MG
¥10,747.66

About This Item

CAS Number:
Beilstein:
1895465
MDL编号:
UNSPSC代码:
41106305
NACRES:
NA.51

¥10,747.66


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生物来源

bovine (calf) thymus

质量水平

类型

Type II-A

表单

lyophilized powder

应用

cell analysis

储存温度

2-8°C

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此商品
P3338P3360SRP6058
biological source

human semen

biological source

human semen

biological source

human

biological source

human

assay

≥99% (SDS-GE)

assay

≥95% (SDS-GE)

assay

≥99% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

lyophilized

shipped in

wet ice

shipped in

-

shipped in

wet ice

shipped in

dry ice

Gene Information

human ... KLK3(354)

Gene Information

human ... KLK3(354)

Gene Information

human ... KLK3(354), SERPINA3(12)

Gene Information

human ... KLK3(354)

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−70°C

一般描述

组蛋白是含有H3、H4、H2A和H2B的八聚体蛋白。它是DNA是围绕其缠绕形成核小体结构的核心蛋白。核心组蛋白包含球状结构域。每个蛋白在其N端均由碱性氨基酸组成。H2A在其C末端具有一个额外的氨基酸,形成组蛋白尾巴。核小体结构在染色质浓缩过程中通过接头组蛋白稳定。[1]

应用

小牛胸腺中的组蛋白已用于:
  • 在甲基转移酶反应混合物中进行甲基转移酶测定[2]
  • 体外结合试验中,探讨了MORF4(4号染色体上的死亡率因子)-15号染色体上相关基因(MRG15)与组蛋白的潜在结合[3]
  • 体外共培养试验中刺激肝脏驻留的Kupffer细胞[4]

生化/生理作用

核心组蛋白参与组蛋白-组蛋白各种相互作用并维持核小体DNA的组织。组蛋白尾巴有助于形成更高阶的核小体结构。染色质纤维的整体结构和作用受组蛋白修饰的调节。[1]

特点和优势

不要将Sigma“类型”名称与Luck及其同事使用的“分级”名称混淆。

制备说明

未分级的全组蛋白

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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