跳转至内容
Merck
CN

H9411

Sigma-Aldrich

Anti-Histone Deacetylase 4 (HDAC4) (ML-19) antibody produced in rabbit

enhanced validation

affinity isolated antibody, buffered aqueous solution

别名:

Anti-AHO3, Anti-BDMR, Anti-HA6116, Anti-HD4, Anti-HDAC-4, Anti-HDAC-A, Anti-HDACA

登录查看公司和协议定价

关于此项目

MDL编号:
MFCD03791601
UNSPSC代码:
12352203
NACRES:
NA.41

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

生物来源

rabbit

质量水平

200

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

antigen ~140 kDa (additional weaker bands may be present)

种属反应性

rat, human, mouse

增强验证

independent
Learn more about Antibody Enhanced Validation

技术

immunoprecipitation (IP): 10-20 μg using RIPA extract of HeLa nuclei
indirect immunofluorescence: 1:250 using HeLa cells
microarray: suitable
western blot: 1:1,000 using whole extracts of mouse NIH3T3 cells
western blot: 1:500 using whole extracts of rat brain

UniProt登记号

P56524

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... HDAC4(9759)
mouse ... Hdac4(208727)
rat ... Hdac4(363287)

相关类别

一般描述

Mammalian histone deacetylases (HDACs) can be divided into three classes according to sequence homology. Class II consists of the yeast Hda1-like proteins histone deacetylase 4,5,6,7,8,9, 10 (HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10.

免疫原

synthetic peptide corresponding to amino acid residues 1-19 of human HDAC4 with C-terminal added lysine conjugated to KLH.

应用

Anti-Histone Deacetylase 4 (HDAC4) (ML-19) antibody produced in rabbit has been used in:
  • immunoblotting
  • immunoprecipitation
  • immunofluorescence
  • immunostaining
  • immunohistochemistry
  • chromatin immunoprecipitation

生化/生理作用

Histone deacetylase 4 (HDAC4) exhibits intrinsic nuclear import and export signals for its dynamic nucleocytoplasmic shuttling. Its association with 14-3-3 and monocyte enhancer factor 2 (MEF2) proteins can disturb shuttling and thus directs HDAC4 to the cytoplasm and the nucleus, respectively.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

未找到合适的产品？  

试试我们的产品选型工具.

储存分类代码

12 - Non Combustible Liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000403928
0000403928
0000254188
0000220373
0000220373

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Lilian Varricchio et al.
The international journal of biochemistry & cell biology, 50, 112-122 (2014-03-07)
To clarify the role of HDACs in erythropoiesis, expression, activity and function of class I (HDAC1, HDAC2, HDAC3) and class IIa (HDAC4, HDAC5) HDACs during in vitro maturation of human erythroblasts were compared. During erythroid maturation, expression of HDAC1, HDAC2
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR
Fischle W, et al.
Molecular Cell, 9(1), 45-57 (2002)
Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4
Sailaja BS, et al.
Proceedings of the National Academy of Sciences of the USA, 109(52), E3687-E3695 (2012)
Histone deacetylase inhibitors preserve white matter structure and function during ischemia by conserving ATP and reducing excitotoxicity
Baltan S, et al.
The Journal of Neuroscience, 31(11), 3990-3999 (2011)
HDAC4 governs a transcriptional program essential for synaptic plasticity and memory
Sando III R, et al.
Cell, 151(4), 821-834 (2012)
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持