H9415
5HPP-33
≥98% (HPLC), solid
别名:
2-[2,6-bis(1-Methylethyl)phenyl]-5-hydroxy-1H-isoindole-1,3(2H)-dione, 5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione
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关于此项目
经验公式（希尔记法）:
C20H21NO3
化学文摘社编号:
分子量:
323.39
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
SMILES string
CC(C)c1cccc(C(C)C)c1N2C(=O)c3ccc(O)cc3C2=O
InChI
1S/C20H21NO3/c1-11(2)14-6-5-7-15(12(3)4)18(14)21-19(23)16-9-8-13(22)10-17(16)20(21)24/h5-12,22H,1-4H3
InChI key
LAKWINYVWJPHQW-UHFFFAOYSA-N
Biochem/physiol Actions
5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules.
5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. 5HPP-33 has shown inhibition of cell proliferation of both estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) breast cancer cells as well as other cell lines. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor (IC50=810 nM).
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves