Merck
CN

H9772

Sigma-Aldrich

5-羟基L-色氨酸

powder

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别名:
L -2-氨基-3-(5-羟基吲哚基)丙酸, L--5-HTP
Empirical Formula (Hill Notation):
C11H12N2O3
CAS号:
分子量:
220.22
EC 号:
MDL编号:
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.77

检测方案

≥98% (TLC)

质量水平

形式

powder

technique(s)

HPLC: suitable

颜色

white to faint beige

储存温度

2-8°C

SMILES string

N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(O)=O

InChI

1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1

InChI key

LDCYZAJDBXYCGN-VIFPVBQESA-N

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此商品
PHR2597T0254107751
5-Hydroxy-L-tryptophan powder

Sigma-Aldrich

H9772

5-羟基L-色氨酸

-
5-Hydroxy-L-tryptophan Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2597

5-羟基L-色氨酸

-
L-Tryptophan reagent grade, ≥98% (HPLC)

Sigma-Aldrich

T0254

L-色氨酸

Essential Grade
5-Hydroxy-L-tryptophan 98% (calc. on dried substance)

Sigma-Aldrich

107751

5-羟基-L-色氨酸

-
form

powder

form

solid

form

powder

form

solid

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

-

technique(s)

-

color

white to faint beige

color

-

color

white to off-white

color

-

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

-

storage temp.

-

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

Gene Information

-

Gene Information

human ... TDO2(6999), TPH1(7166), TPH2(121278)

Gene Information

-

一般描述

5-羟基-L-色氨酸(5-HTP)天然存在于加纳籽(Griffonia simplicifolia)中。

应用

5-羟基-L-色氨酸已用于:
  • 注射实验小鼠进行血清素检测
  • 作为5-羟色胺前体注入怀孕小鼠和新生大鼠,用于进行肺切片的中性红活体染色
  • 作为柠檬酸-乙酸缓冲液用标准品,用于高效液相色谱(HPLC)分析。

生化/生理作用

L-色氨酸的羟化反应在大脑的血清素合成过程中进行。该步骤调控血清素的生产,并生成5-羟基-l-色氨酸(5-HTP)代谢物。因此服用5-羟色氨酸(5-HTP)会提高血清素水平,导致抑郁、睡眠不足和剧烈头痛。
血清素的直接前体; L -芳香族氨基酸脱羧酶底物。

注意

感光

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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The British Journal of Nutrition, 111(S1), S23-S29 (2014)
M G Marrero et al.
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商品

Serotonin Synthesis and Metabolism

Serotonin (5-hydroxytryptamine) is principally found stored in three main cell types - i) serotonergic neurons in the CNS and in the intestinal myenteric plexus, ii) enterochromaffin cells in the mucosa of the gastrointestinal tract, and iii) in blood platelets. Metabolism of serotonin is carried out primarily by the outer mitochondrial membrane enzyme monoamine oxidase (MAO), which occurs as two molecular subtypes called MAO-A and MAO-B.

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