HPA003324
抗-SLC16A1 兔抗
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
抗-MCT 1, 抗-单羧酸转运蛋白 1, 抗-溶质载体家族 16 成员 1
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC
Citations:
15
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
technique(s)
immunoblotting: 0.04-0.4 μg/mL, immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:500-1:1000
immunogen sequence
PTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQEKRSVFQTINQFLDLTLFTHRGF
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SLC16A1(6566)
General description
溶质载体家族16成员1 (SLC16A1) 基因全长44kb，定位于人染色体1p13.2-p12区。编码蛋白MCT1属于单羧酸转运蛋白 (MCT) 家族。
Immunogen
单羧酸盐转运蛋白 1 重组蛋白表位信号标签（PrEST）
Application
SLC16A1兔抗可用于免疫染色和免疫印迹。
兔产生的抗SLC16A1抗体，属于Prestige 抗体，由人类蛋白质图谱（HPA）项目开发和验证。每种抗体都通过针对数百种正常和疾病组织的免疫组织化学进行测试。通过单击图像库链接，可以在人类蛋白质图谱（HPA）站点上查看这些图像。还采用免疫荧光和蛋白质印迹法对抗体进行检测。想要查看有关Prestige 抗体和HPA的方案和其他实用信息，请访问 sigma.com/prestige。
Biochem/physiol Actions
溶质载体家族16成员1 (SLC16A1) 基因编码质子耦合单羧酸转运蛋白。这种蛋白催化多种单羧酸的转运，包括乳酸、丙酮酸、乙酰乙酸、β-羟丁酸和乙酸，是营养物质正常同化的必需蛋白。它在基底样乳腺癌中与乳酸脱氢酶共表达。它有在肿瘤细胞中表达。它可作为高风险神经母细胞瘤的潜在治疗靶点。SLC16A1突变会引起严重的酮症酸中毒，特征是酮体的肝内生成和肝外利用失衡。
Features and Benefits
Prestige抗体®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige抗体对其他蛋白质的独特性和低交叉反应性®是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。针对每一个Prestige Antibody都存在有对应的Prestige抗原对照，并可在链接区域内找到。
每个Prestige Antibody都是按照以下方法进行测试的：
每个Prestige Antibody都是按照以下方法进行测试的：
- 44例正常人类组织以及20例最常见癌症类型组织的IHC组织阵列。
- 364个人类重组蛋白片段的蛋白阵列。
Physical form
溶于磷酸盐缓冲盐水，pH 7.2，含有40%甘油和0.02%叠氮化钠
Other Notes
相应抗原APREST86072
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 1
法规信息
低风险生物材料
常规特殊物品
常规特殊物品
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Prestige Antibodies Immunofluorescence Procedure
I Tamai et al.
Biochemical and biophysical research communications, 214(2), 482-489 (1995-09-14)
A molecular mechanism for the intestinal monocarboxylic acid transport was characterized by using a proton/monocarboxylate transporter, MCT1, in Chinese hamster ovary (CHO) cells, first found by Garcia et al. (Cell, 76, 865-873, 1994). Northern blotting analysis showed that MCT1-isomers exist
Peter M van Hasselt et al.
The New England journal of medicine, 371(20), 1900-1907 (2014-11-13)
Ketoacidosis is a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. We performed exome sequencing in a patient with recurrent, severe ketoacidosis and identified a homozygous frameshift mutation in the gene encoding
Jun Fang et al.
Molecular pharmacology, 70(6), 2108-2115 (2006-09-27)
Neuroblastomas produce high amounts of lactic acid and upregulate the H(+)-linked monocarboxylate transporter isoform 1 (MCT1/SLC16A1). We found elevated MCT1 mRNA levels in fresh neuroblastoma biopsy samples that correlated positively with risk of fatal disease and amplification of the "proto-oncogenic"
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| HPA003324-25UL | 04061842813513 |
| HPA003324-100UL | 04061837134456 |