Anti-MYRIP antibody produced in rabbit

MYRIP (myosin VIIA and Rab interacting protein) is a Rab27a-interacting protein, and is highly expressed in human umbilical vein endothelial cells (HUVECs). It is localized to mature and peripheral endothelial cell secretory bodies called Weibel-Palade bodies (WPBs).

myosin VIIA and Rab interacting protein recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

MYRIP (myosin VIIA and Rab interacting protein), along with Rab27a, anchors Weibel-Palade bodies (WPBs) to actin cytoskeleton to aid in their peripheral localization. As von Willebrand factor (VWF) is the major cargo of WPBs, MYRIP controls the release of VWF from endothelial cells. It suppresses exocytosis in PC12 cells, but enhances the release of insulin. In human and monkey testis, this protein localizes to manchette, and thus, might be involved in intramanchette transport during spermiogenesis.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Corresponding Antigen APREST79913

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