Anti-VMA21 antibody produced in rabbit

VMA21 (vacuolar membrane ATPase activity 21 (VMA21)) is a diverged ortholog of yeast Vma21p protein, which is found in humans. VMA21 forms a part of the vacuolar ATPases (V-ATPases), which are expressed in the endomembrane systems of all eukaryotes. It has 14 subunits arranged in two domains, transmembrane V₀ domain and cytoplasmic V₁ domain. In humans, this gene is localized to chromosome Xq28.

UPF0569 transmembrane protein LOC203547 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

VMA21 (vacuolar membrane ATPase activity 21 (VMA21)) initiates the assembly of the V₀ domain, which acts as a proton-translocator, of vacuolar ATPases (V-ATPases). It interacts with the c′′ subunit of V₀ domain. It transports this domain from endoplasmic reticulum to Golgi bodies, in COPII vesicles. V-ATPases are required to maintain the acidity of lysosomes, as well as the pH gradient of the endovesicular secretory pathways. Therefore, inactivation of VMA21 leads to an increase in the lysosomal pH. Mutations in this gene lead to X-linked myopathy with excessive autophagy (XMEA), which is characterized by vacuolation and atrophy of skeletal muscles.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Corresponding Antigen APREST74403

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