Anti-AGAP3 antibody produced in rabbit

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AGAP3 (ADP ribosylation factor GTPase activating protein (Arf-GAP) with GTPase, ankyrin (ANK) repeat and Pleckstrin homology domain (PH) domain-containing protein 3) has been shown to form nuclear inclusions in response to stress. It induces a ring-like structure of promyelocytic leukemia protein (PML) body. The degradation of polyglutamine (polyQ) at promyelocytic leukemia (PML) bodies is carried out by AGAP3 through the ubiquitin-proteasome pathway. The knockdown of AGAP3 blocks the nuclear translocation of polyQ and also enhances cell death mediated by polyQ. It has been suggested that AGAP3 is involved in the pathogenesis of polyglutamine diseases.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

AGAP3 (ADP ribosylation factor GTPase activating protein (Arf-GAP) with GTPase, ankyrin (ANK) repeat and pleckstrin homology domain (PH) domain-containing protein 3) is a guanosine triphosphatase (GTPase) which contains a nuclear localization signal (NLS) sequence. It is expressed in the brain and heart. It contains multiple domains involved in signaling like a GTPase-like domain, a PH domain and an ArfGAP domain. AGAP3 exists as a component of the N-methyl-D-aspartate receptor (NMDA) receptor complex.

Arf-GAP, GTPase, ANK repeat and pH domain-containing protein 3 recombinant protein epitope signature tag (PrEST)

Corresponding Antigen APREST86953

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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