HPA013189
Anti-TCF21 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-POD1, Anti-bHLHa23, Anti-transcription factor 21
产品名称
Anti-TCF21 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
technique(s)
immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:50-1:200
immunogen sequence
LSDVEDLQEVEMLECDGLKMDSNKEFVTSNESTEESSNCENGSPQKGRGGLGKRRKAPTKKSPLSGVSQEGKQV
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TCF21(6943)
Application
Anti-TCF21 antibody produced in rabbit has been used in:
- immunofluorescence
- flow cytometry
- chromatin immunoprecipitation
Biochem/physiol Actions
Transcription factor TCF21 (TCF21) regulates mesenchymal-to-epithelial differentiation and smooth muscle cells (SMCs) phenotypic modulation. The deletion of TCF21 gene leads to SMC upregulation. Hypermethylation of TCF21 is implicated in non-small cell lung cancer (NSCLC). TCF21 is a tumor suppressor and is involved in the invasion and metastasis. Elevated expression of TCF21 leads to hepatocellular cancer suppression. It also elicits anti-angiogenic activity in cholangiocarcinoma. TCF21 locus is also associated with coronary heart disease(CAD).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
General description
Transcription factor TCF21 (TCF21) or capsulin, expressed in proepicardial cells is mapped to human chromosome 6q23.2.
Immunogen
transcription factor 21 recombinant protein epitope signature tag (PrEST)
Other Notes
Corresponding Antigen APREST85233
Physical form
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
法规信息
常规特殊物品
此项目有
Felix Kliewe et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 55(S4), 48-67 (2021-06-21)
Podocyte differentiation is essential for proper blood filtration in the kidney. It is well known that transcription factors play an essential role to maintain the differentiation of podocytes. The present study is focused on the basic helix-loop-helix (bHLH) transcription factor
Thomas J Streef et al.
Stem cell reports, 18(7), 1421-1435 (2023-07-01)
The epicardium plays an essential role in cardiogenesis by providing cardiac cell types and paracrine cues to the developing myocardium. The human adult epicardium is quiescent, but recapitulation of developmental features may contribute to adult cardiac repair. The cell fate
Juyong Brian Kim et al.
PLoS genetics, 13(5), e1006750-e1006750 (2017-05-10)
Both environmental factors and genetic loci have been associated with coronary artery disease (CAD), however gene-gene and gene-environment interactions that might identify molecular mechanisms of risk are not easily studied by human genetic approaches. We have previously identified the transcription
Quanyi Zhao et al.
Genome biology, 21(1), 135-135 (2020-06-10)
To investigate the epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the functional regulation of chromatin structure and function, we create a catalog of genetic variants associated with three stages of transcriptional cis-regulation in primary
Olga Sazonova et al.
PLoS genetics, 11(5), e1005202-e1005202 (2015-05-29)
To functionally link coronary artery disease (CAD) causal genes identified by genome wide association studies (GWAS), and to investigate the cellular and molecular mechanisms of atherosclerosis, we have used chromatin immunoprecipitation sequencing (ChIP-Seq) with the CAD associated transcription factor TCF21
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