Anti-SRPK2 antibody produced in rabbit

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SRPK2 (serine/arginine- rich protein-specific kinase 2) leads to elevated expression cyclin A1, by interacting with and binding acinus protein. This protein is a Ser/Arg (SR), which plays an essential role in the splicing of RNA. Phosphorylation of this protein by SRPK2 results in the movement of this protein to nucleoplasm from nucleus speckles. Acinus protein mediates cell growth and proliferation. The expression of both these proteins is up-regulated in human myeloid hematological malignancies. SRPK2 also phosphorylates Srp75, an SR protein, which results in elevated expression of human immunodeficiency virus (HIV). It phosphorylates the RS motif of BLRF2 protein of Epstein-Barr virus (EBV), which is essential for the replication of EBV. It is also essential for the replication of hepatitis C virus, and thus has potential as a therapeutic target for novel antiviral agents.

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Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

SRPK2 (serine/arginine- rich protein-specific kinase 2) belongs to the family of mitosis-regulated kinases called SRPK. This protein primarily resides in the cytoplasm, and contains bipartite kinase domains, which are separated by a spacer region. This protein has a molecular weight of 115kDa.

Serine/threonine-protein kinase SRPK2 recombinant protein epitope signature tag (PrEST)

Corresponding Antigen APREST73485

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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