Anti-PIP5K1C antibody produced in rabbit

Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma (PIP5K1C) belongs to the PIPKIγ family. It is majorly expressed in the brain. The PIP5K1C gene is mapped to human chromosome 19p13.3.

Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma recombinant protein epitope signature tag (PrEST)

Corresponding Antigen APREST72490

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma (PIP5K1C) generates phosphatidylinositol 4,5-bisphosphate (PIP2) by phosphorylating the fifth hydroxyl group of phosphatidylinositol-4-phosphate (PI4P). The copy number amplifications of the PIP5K1C gene are implicated in glioblastoma multiforme. Mutation in the PIP5K1C gene leading to functional abrogation may affect the phosphatidylinositol pathway and its synthesis. PIP5K1C participates in receptor-mediated calcium signaling, endocytosis, and exocytosis. PIP5K1C may serve as a therapeutic target for chronic pain.

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Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.