Anti-RAPH1 antibody produced in rabbit

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The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1) is involved in the regulation of actin cytoskeleton assembly. It directly binds to the Ena/VASPs proteins to guide the cells in movement and lamelipodial protrusion. It modulates actin polymerization by binding to different phosphoinositol through Ras GTPase signaling pathway. RAPH1 also possesses tumorigenic characteristics. It controls the cell motility of breast tumor cells. Deleted expression of RAPH1 has been reported in various types of cancer cells such as breast carcinoma.

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Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1) is a RA-PH tandem domain containing protein encoding an adaptor protein termed as lamellipodin protein (Lpd). It is located on the chromosome location 2q33. It also consists of an N-terminal coiled-coil region (cc-RA-PH).

Ras-associated and pleckstrin homology domains-containing protein 1 recombinant protein epitope signature tag (PrEST)

Corresponding Antigen APREST74658

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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