HPA023887
Anti-FYN antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-Proto-oncogene tyrosine-protein kinase Fyn, Anti-Protooncogene Syn, Anti-SLK, Anti-p59-Fyn
产品名称
Anti-FYN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
mouse, human, rat
enhanced validation
RNAi knockdown
Learn more about Antibody Enhanced Validation
technique(s)
immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:50-1:200
immunogen sequence
SFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIR
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... FYN(2534)
Application
Anti-FYN antibody has been used in western blotting and sodium dodecyl sulphate-polyacrylamide gel electrophoresis.
Anti-FYN antibody produced in rabbit has been used for Western blotting. All Prestige Antibodies®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
FynT, an isoform of tyrosine-protein kinase Fyn, regulates neurofibrillary degeneration and reactive astrogliosis in Alzheimer′s disease (AD). The tyrosine kinase Fyn plays a vital role in acute transplant rejection, by phosphorylating tyrosine residues on key targets that take part in early T-cell signal transduction, which is a crucial process for acute transplant rejection. p59fyn (T) controls OKT3 promoted calcium ion transport in Jurkat T cells . Fyn facilitates the phosphorylation of Vav, a guanine nucleotide exchange factor for Rho-like small GTPases, and plays a crucial role in TCR-mediated actin polymerization. The Fyn protein associates with large myelin-associated glycoprotein (MAG) and plays a major role in myelinogenesis.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
General description
FYN (proto-oncogene, Src family tyrosine kinase) is located in human chromosome 6q21.
Fyn is a non-receptor type tyrosine kinase also called as tau kinase, which belongs to the Src family. It has two isoforms, FynB and FynT, expressed in brain and T-lymphocytes, respectively. The Fyn protein consist of Src homology domain 2 (SH2) and Src homology domain 3 (SH3) at its amino terminal ends.
Immunogen
FYN proto-oncogene, Src family tyrosine kinase
Other Notes
Corresponding Antigen APREST78892
Physical form
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase.
Huang J
Proceedings of the National Academy of Sciences of the USA, 97(20), 10923-10929 (2000)
Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease.Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease.
Lau DH
Acta Neuropathologica Communications, 4(1):49 (2016)
Role of Fyn-mediated NMDA receptor function in prediabetic neuropathy in mice.
Suo M, et al.
Journal of Neurophysiology, 116(2), 448-455 (2016)
Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines.
Weil R
Journal of Virology, 73(5), 3709-3717 (1999)
Dawn H W Lau et al.
Acta neuropathologica communications, 4(1), 49-49 (2016-05-20)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by neuropathological deposits of amyloid plaques and neurofibrillary tangles comprised of β-amyloid and tau protein, respectively. In AD, tau becomes abnormally phosphorylated and aggregates to form intracellular deposits. However, the mechanisms
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