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HPA024185

抗-RBCK1 兔抗

Name: 抗-RBCK1 兔抗
Brand: SIGMA

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

别名:

抗-C20orf18, 抗-HOIL1, 抗-RBCK2, 抗-RNF54, 抗-UBCE7IP3, 抗-XAP4, 抗-ZRANB4

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.43

Human Protein Atlas Number:

HPA024185

Conjugate:

unconjugated

Clone:

polyclonal

Application:

—

Citations:

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属性

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies^® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

technique(s)

immunoblotting: 0.04-0.4 μg/mL

immunogen sequence

SVEDAQMHTVTIWLTVRPDMTVASLKDMVFLDYGFPPVLQQWVIGQRLARDQETLHSHGVRQNGDSAYLYLLSARNTSLNPQELQRERQLRMLEDLGFKDLTLQPRGPLEPGPPKPGVPQEPGRGQPDAVPEP

UniProt accession no.

Q9BYM8

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RBCK1(10616)

说明

Immunogen

含有RanBP型和C3HC4型锌指蛋白质1重组蛋白表位标签（PrEST）

Application

成功使用该抗体的应用以及相关的同行评审论文如下所示。
蛋白质印迹（1篇论文）

Features and Benefits

Prestige Antibodies^®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige Antibodies^®对其他蛋白质的独特性和低交叉反应性是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。每种Prestige 抗体都有相应的Prestige 抗原对照品，可在链接部分找到。

每种Prestige 抗体的检测方法如下：

44种正常人体组织和20种最常见癌症组织的IHC组织阵列。
364个人重组蛋白片段的蛋白阵列。

Physical form

磷酸盐缓冲盐水溶液，pH 7.2，含有40%甘油和0.02%叠氮化钠

Other Notes

相应抗原APREST86460

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品

低风险生物材料

常规特殊物品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

A89708

R12587

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Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis.

Yesheng Fu et al.

Nature communications, 15(1), 2974-2974 (2024-04-07)

Linear ubiquitination catalyzed by HOIL-1-interacting protein (HOIP), the key component of the linear ubiquitination assembly complex, plays fundamental roles in tissue homeostasis by executing domain-specific regulatory functions. However, a proteome-wide analysis of the domain-specific interactome of HOIP across tissues is

HOIL-1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation.

Ian R Kelsall et al.

The EMBO journal, 41(8), e109700-e109700 (2022-03-12)

HOIL-1, a component of the linear ubiquitin chain assembly complex (LUBAC), ubiquitylates serine and threonine residues in proteins by esterification. Here, we report that mice expressing an E3 ligase-inactive HOIL-1[C458S] mutant accumulate polyglucosan in brain, heart and other organs, indicating

Normal lymphocyte homeostasis and function in MALT1 protease-resistant HOIL-1 knock-in mice.

Ioannis Skordos et al.

The FEBS journal, 290(8), 2032-2048 (2022-12-09)

The uniqueness of MALT1 protease activity in controlling several aspects of immunity in humans has made it a very attractive therapeutic target for multiple autoimmune diseases and lymphoid malignancies. Despite several encouraging preclinical studies with MALT1 inhibitors, severe reduction in

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全球贸易项目编号

货号	GTIN
HPA024185-25UL	04061842844234
HPA024185-100UL	04061837127045