HPA029005
抗-SRSF6 兔抗
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
抗-B52, 抗-SFRS6, 抗-SRP55, 抗-剪接因子，富含精氨酸/丝氨酸6
产品名称
抗-SRSF6 兔抗, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human, mouse
enhanced validation
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
technique(s)
immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:50-1:200
immunogen sequence
KDEYEKSRSRSRSRSPKENGKGDIKSKSRSRSQSRSNSPLPVPPSKARSVSPPPKRATSRSR
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SFRS6(6431)
相关类别
Biochem/physiol Actions
SRSF6（富含丝氨酸/精氨酸的剪接因子6）参与BimS（Bcl2细胞死亡相调节子）mRNA的产生。它还在Zn2+-诱导的BimS产生中发挥至关重要的作用。它参与组成性剪接和选择性剪接。它刺激致敏皮肤的增生。它是一种常在人类皮肤癌中表达的原癌基因。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Application
兔抗-SRSF6 抗体还可用于蛋白质印迹。
Features and Benefits
Prestige抗体®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige抗体对其他蛋白质的独特性和低交叉反应性®是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。针对每一个Prestige Antibody都存在有对应的Prestige抗原对照，并可在链接区域内找到。
每个Prestige Antibody都是按照以下方法进行测试的：
每个Prestige Antibody都是按照以下方法进行测试的：
- 44例正常人类组织以及20例最常见癌症类型组织的IHC组织阵列。
- 364个人类重组蛋白片段的蛋白阵列。
General description
SRSF6（丝氨酸/精氨酸丰富剪接因子6）又称SRp55。它是富含精氨酸/丝氨酸的剪接因子家族的成员。作为主要剪接因子之一，它在没有p53的DNA损伤时可以上调。
Immunogen
剪接因子，富含精氨酸/丝氨酸的 6 重组蛋白表位信号标签（PrEST）
Other Notes
对应抗原APREST77719
Physical form
磷酸盐缓冲盐溶液，pH 7.2，含有 40% 甘油和 0.02% 叠氮化钠。
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Zinc-induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS
Hara H, et al.
FEBS Journal, 280(14), 3313-3327 (2013)
Splicing factor SRSF6 promotes hyperplasia of sensitized skin
Jensen MA, et al.
Nature Structural and Molecular Biology, 21(2), 189-197 (2014)
Comparative expression patterns and diagnostic efficacies of SR splicing factors and HNRNPA1 in gastric and colorectal cancer
Park WC, et al.
BMC Cancer, 16 (2016)
Won Cheol Park et al.
BMC cancer, 16, 358-358 (2016-06-11)
Serine/arginine-rich splicing factors (SRSFs) and HNRNPA1 have oncogenic properties. However, their proteomic expressions and practical priority in gastric cancer (GC) and colorectal cancer (CRC) are mostly unknown. To apply SFs in clinics, effective marker selection and characterization of properties in
Agnieszka Girstun et al.
Journal of cellular biochemistry (2019-02-19)
Subnuclear localization of topoisomerase I (top I) is determined by its DNA relaxation activity and a net of its interactions with in majority unidentified nucleolar and nucleoplasmic elements. Here, we recognized SR protein SRSF1 (Serine/arginine-rich splicing factor 1, previously known
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