HPA029029
Anti-ETHE1 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, ab3
别名:
Anti-FLJ10737, Anti-HSCO, Anti-YF13H12, Anti-ethylmalonic encephalopathy 1
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
mouse, human, rat
enhanced validation
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
technique(s)
immunoblotting: 0.04-0.4 μg/mL, immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:1000-1:2500
immunogen sequence
RTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAHDYHGFTVSTVEEERTLNPRLTLSCEEFVKIMGNLNLPKPQQIDFAVPANMRCG
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ETHE1(23474)
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General description
ETHE1 (persulfide/sulfur dioxygenase) is a member of metallo-β-lactamase superfamily. It codes for a β-lactamase–like, iron-coordinating metalloprotein. It consists of a mononuclear iron in its active site. In eukaryotes, it is found within the mitochondrial matrix.
Immunogen
ethylmalonic encephalopathy 1 recombinant protein epitope signature tag (PrEST)
Application
Anti-ETHE1 antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
ETHE1 (persulfide/sulfur dioxygenase) participates in the catabolism of sulfide that accumulates to toxic levels in ethylmalonic encephalopathy. ETHE1 can transform persulfides to sulfite in the mitochondrial sulfide oxidation pathway. Mutations in ETHE1 cause ethylmalonic encephalopathy.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Physical form
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Other Notes
Corresponding Antigen APREST77869
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Spectroscopic studies on Arabidopsis ETHE1, a glyoxalase II-like protein.
Holdorf MM, et al.
Journal of Inorganic Biochemistry, 102(9), 1825-1830 (2008)
CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.
EMBO Molecular Medicine, 9(1), 78-95 (2017)
Characterization of patient mutations in human persulfide dioxygenase (ETHE1) involved in H2S catabolism.
Kabil O and Banerjee R
The Journal of Biological Chemistry, 287(53), 44561-44567 (2012)
Pilar González-García et al.
Human molecular genetics, 29(19), 3296-3311 (2020-09-26)
Abnormalities of one carbon, glutathione and sulfide metabolisms have recently emerged as novel pathomechanisms in diseases with mitochondrial dysfunction. However, the mechanisms underlying these abnormalities are not clear. Also, we recently showed that sulfide oxidation is impaired in Coenzyme Q10
Marta Luna-Sánchez et al.
EMBO molecular medicine, 9(1), 78-95 (2016-11-20)
Coenzyme Q (CoQ) is a key component of the mitochondrial respiratory chain, but it also has several other functions in the cellular metabolism. One of them is to function as an electron carrier in the reaction catalyzed by sulfide:quinone oxidoreductase
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