Anti-FRMD4A antibody produced in rabbit

FERM domain containing 4A (FRMD4A) is a member of the four-point-one, ezrin, radixin, moesin (FERM) superfamily of proteins. As the name suggests, the protein contains FERM domain, which is implicated in linking transmembrane proteins to the cytoskeleton, regulation of cell morphology, protein localization and tumor cell migration. It is encoded by the gene mapped to human chromosome 10p13.

FERM domain containing 4A recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Four-point-one, ezrin, radixin, moesin (FERM) family proteins play a vital role in various cellular functions including, cell transport, cell structure and signaling functions. In addition, it is also associated with tumor progression and metastasis. Upregulated expression of FRMD4A triggers growth of head and neck squamous cell carcinomas. The encoded protein modulates cell polarity by triggering the activation of ADP-ribosylation factor 6 (ARF6) and connecting Par3 and the ARF6 guanine nucleotide exchange factor, cytohesin-1. Variations in the gene expression results in Alzheimer′s disease.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Corresponding Antigen APREST80289

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