I0157
Ibudilast
≥99% (HPLC), Phosphodiesterase IV inhibitor, solid
别名:
2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone, 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C14 H18 N2 O
化学文摘社编号:
分子量:
230.31
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Ibudilast, ≥99% (HPLC), solid
Quality Level
assay
≥99% (HPLC)
form
solid
color
white
solubility
DMSO: soluble 28 mg/mL, H2O: soluble 4.5 mg/mL
storage temp.
2-8°C
SMILES string
CC(C)C(=O)c1c(nn2ccccc12)C(C)C
InChI
1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3
InChI key
ZJVFLBOZORBYFE-UHFFFAOYSA-N
Gene Information
human ... PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)
Biochem/physiol Actions
Phosphodiesterase IV (PDE4) inhbitor. Inhibits platelet aggregation. Anti-asthma drug.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
相关内容
Datasheet
Masahiro Noguchi et al.
Biological & pharmaceutical bulletin, 32(11), 1924-1927 (2009-11-03)
Ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine) is clinically used as a cerebral vasodilator in Japan. However, the effects of ibudilast on retinal blood vessels have not been fully examined. The aim of this study, therefore, was to examine the effects of ibudilast on retinal
F Barkhof et al.
Neurology, 74(13), 1033-1040 (2010-03-05)
Ibudilast is a phosphodiesterase inhibitor influencing inflammation and neurodegeneration in multiple sclerosis (MS). This study evaluated the safety, tolerability, and effects on MRI parameters of 2 different doses of ibudilast in relapsing forms of MS. In this multicenter, double-blind, phase
Primary neuroprotection: the Holy Grail of multiple sclerosis therapy.
Robert J Fox
Neurology, 74(13), 1018-1019 (2010-03-05)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| I0157-10MG | 04061833271643 |
| I0157-50MG | 04061833271650 |