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安全信息

I0157

Sigma-Aldrich

Ibudilast

≥99% (HPLC), solid

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别名:
2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone, 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404
经验公式（希尔记法）:
C14 H18 N2 O
CAS号:
50847-11-5
分子量:
230.31
MDL编号:
MFCD00864808
PubChem化学物质编号:
24278482
NACRES:
NA.77

检测方案

≥99% (HPLC)

形式

solid

颜色

white

溶解性

DMSO: soluble 28 mg/mL
H2O: soluble 4.5 mg/mL

储存温度

2-8°C

SMILES string

CC(C)C(=O)c1c(nn2ccccc12)C(C)C

InChI

1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3

InChI key

ZJVFLBOZORBYFE-UHFFFAOYSA-N

Gene Information

human ... PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)

生化/生理作用

Phosphodiesterase IV (PDE4) inhbitor. Inhibits platelet aggregation. Anti-asthma drug.

特点和优势

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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Masahiro Noguchi et al.
Biological & pharmaceutical bulletin, 32(11), 1924-1927 (2009-11-03)
Ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine) is clinically used as a cerebral vasodilator in Japan. However, the effects of ibudilast on retinal blood vessels have not been fully examined. The aim of this study, therefore, was to examine the effects of ibudilast on retinal
Primary neuroprotection: the Holy Grail of multiple sclerosis therapy.
Robert J Fox
Neurology, 74(13), 1018-1019 (2010-03-05)
F Barkhof et al.
Neurology, 74(13), 1033-1040 (2010-03-05)
Ibudilast is a phosphodiesterase inhibitor influencing inflammation and neurodegeneration in multiple sclerosis (MS). This study evaluated the safety, tolerability, and effects on MRI parameters of 2 different doses of ibudilast in relapsing forms of MS. In this multicenter, double-blind, phase
Michelle Kiebala et al.
PloS one, 6(4), e18633-e18633 (2011-04-16)
Human Immunodeficiency Virus-1 (HIV-1)-associated neurocognitive disorders (HAND) occur, in part, due to the inflammatory response to viral proteins, such as the HIV-1 transactivator of transcription (Tat), in the central nervous system (CNS). Given the need for novel adjunctive therapies for
Hwa Yoon et al.
Biomedical chromatography : BMC, 24(3), 324-328 (2009-07-25)
A simple, accurate, precise and cost effective reversed-phase HPLC method was developed to determine the concentration of ibudilast in human serum. Ibudilast and an internal standard, butyl 4-hydroxybenzoate, were extracted by liquid-liquid extraction with methyl tert-butyl ether. HPLC analysis was
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