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Merck
CN

I0160

Sigma-Aldrich

亚胺培南 一水合物

≥98% (HPLC), B-lactam antibiotic, powder

别名:

Primaxin 一水合物, Tienam 一水合物, （5R，6S）-6-[（（1R）-1-羟基乙基] -3-[[2-[（亚氨基甲基）氨基]乙基]硫代] -7-氧代-1-氮杂双环[3.2.0] hept-2 -烯-2-羧酸 一水合物

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关于此项目

经验公式（希尔记法）:
C12H17N3O4S · H2O
化学文摘社编号:
74431-23-5
分子量:
317.36
EC 号:
264-734-5
MDL编号:
MFCD09753321
UNSPSC代码:
12352200
PubChem化学物质编号:
329815301
NACRES:
NA.77

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产品名称

亚胺培南 一水合物, ≥98% (HPLC)

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white

抗生素抗菌谱

mycobacteria

作用机制

cell wall synthesis | interferes

创始人

Merck & Co., Inc., Kenilworth, NJ, U.S.

储存温度

−20°C

SMILES字符串

O.C[C@@H](O)[C@@H]1[C@H]2CC(SCCNC=N)=C(N2C1=O)C(O)=O

InChI

1S/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1

InChI key

GSOSVVULSKVSLQ-JJVRHELESA-N

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相关类别

一般描述

Chemical structure: ß-lactam

应用

Imipenem monohydrate has been used to determine the resistance profiles of Pseudomonas aeruginosa isolates. It has also been used in susceptibility testing against Acinetobacter baumannii.

生化/生理作用

亚胺培南一水合物是广谱 B -内酰胺抗生素。
亚胺培南一水合物是广谱 B -内酰胺抗生素。 它是碳青霉烯类“魔弹”抗生素的一种，用于严重感染。
Imipenem is found effective against gram positive and negative aerobes and anaerobes. Imipenem is often combined with cilastatin, to inhibit its metabolism in kidney.

特点和优势

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000418193
0000418193
0000405322
0000384966
0000311736

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Antibiotic and chemotherapy e-book, 234-234 (2010)
David M Livermore et al.
The Journal of antimicrobial chemotherapy, 68(10), 2286-2290 (2013-05-23)
MK-7655 is a novel inhibitor of class A and C β-lactamases. We investigated its potential to protect imipenem. Chequerboard MICs were determined by CLSI agar dilution: (i) for Enterobacteriaceae with carbapenemases; (ii) for Enterobacteriaceae with carbapenem resistance contingent on combinations
Could plazomicin alone or in combination be a therapeutical option against carbapenem-resistant Acinetobacter baumannii?
Garcia Salguero C, et al.
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Acta crystallographica. Section D, Biological crystallography, 69(Pt 9), 1697-1706 (2013-09-04)
The modelling of peptidoglycan is responsible for key cellular processes in Mycobacterium tuberculosis such as cell growth, division and resuscitation from dormancy. The structure of M. tuberculosis peptidoglycan is atypical since it contains a majority of 3,3 cross-links synthesized by L,D-transpeptidases
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Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

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