I0274
myo-Inositol Monophosphatase from bovine brain
lyophilized powder, 5-20 units/mg protein
别名:
myo-Inositol monophosphate phosphohydrolase
表单
lyophilized powder
比活
5-20 units/mg protein
组成
Protein, ~0.5% Bradford
储存温度
−20°C
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应用
The enzyme plays a critical role in the recycling of inositol to phosphoinositides in the mammalian brain and participates in the phosphatidylinositol signaling pathway. It is inhibited non-competitively by Li+, which may be significant in the treatment of manic depression. The enzyme may help in identifying less toxic substitutes for lithium in manic depressive therapy.
外形
Lyophilized powder containing HEPES buffer salts, pH 7.5, and stabilizer
其他说明
One unit will form 1.0 μmole of phosphate from inositol 1-phosphate per min at pH 7.4 at 37°C.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Svetlana Kalujnaia et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(10), 3981-3991 (2010-06-16)
This study investigated the expression and tissue distribution of inositol monophosphatase (IMPA1) and characterized its role in salinity adaptation in the eel. The coding sequence of eel IMPA1 was determined and confirmed to be orthologous to the mammalian gene/enzyme by
S J Pollack et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(13), 5766-5770 (1994-06-21)
myo-Inositol monophosphatase (myo-inositol-1-phosphate phosphohydrolase, EC 3.1.3.25) is an attractive target for mechanistic investigation due to its critical role in the phosphatidylinositol signaling pathway and the possible relevance of its inhibition by Li+ to manic depression therapy. The x-ray crystallographic structure
Christopher A Broberg et al.
Science (New York, N.Y.), 329(5999), 1660-1662 (2010-08-21)
The marine bacterium Vibrio parahaemolyticus causes gastroenteritis in humans and encodes the type III effector protein VPA0450, which contributes to host cell death caused by autophagy, cell rounding, and cell lysis. We found that VPA0450 is an inositol polyphosphate 5-phosphatase
Inge De Meyer et al.
British journal of pharmacology, 162(6), 1410-1423 (2010-12-09)
Lithium chloride (LiCl) inhibits inositol monophosphatase (IMPase) at therapeutic concentrations. Given that LiCl induces death in cultured macrophages and that macrophages play an active role in atherosclerotic plaque destabilization, we investigated whether LiCl would induce selective macrophage death to stabilize
Sudipta Bhattacharyya et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 67(Pt 4), 471-474 (2011-04-21)
The gene product of the sas2203 ORF of Staphylococcus aureus MSSA476 encodes a 30 kDa molecular-weight protein with a high sequence resemblance (29% identity) to tetrameric inositol monophosphatase from Thermotoga maritima. The protein was cloned, expressed, purified to homogeneity and crystallized.
相关内容
Datasheet
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