I0404
靛玉红-3′ -单肟
≥98% (HPLC), solid
别名:
靛玉红-3′-肟
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关于此项目
经验公式（希尔记法）:
C16H11N3O2
化学文摘社编号:
分子量:
277.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,17,21H,(H,18,20)/b15-13-,19-14+
SMILES string
O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4ccccc34
InChI key
HBDSHCUSXQATPO-BGBJRWHRSA-N
assay
≥98% (HPLC)
form
solid
mol wt
277.28
solubility
DMSO: >10 mg/mL, H2O: insoluble
storage temp.
room temp
Quality Level
Application
靛红-3′-肟已被用于抑制人单核细胞系THP-1中的糖原合酶激酶3。
Biochem/physiol Actions
靛红-3′-肟在Jurkat T细胞中可介导凋亡，并具有抗肿瘤功能。 靛红-3′-肟可抑制Y框结合蛋白1（YB1）的易位，有助于抗癌功能。 靛红-3′-肟可降低人神经母细胞瘤中雌激素相关受体γ (ERRγ)和过氧化物酶体增殖物激活的受体-γ 共激活因子-1α (PGC1α)的表达，从而导致细胞周期停滞和线粒体功能障碍。
靛红-3′-肟是一种细胞周期蛋白依赖性激酶抑制剂，可通过与ATP竞争结合催化亚基而发挥功能。其具有抗增殖活性，可导致许多细胞系中的G2/M停滞和Jurkat细胞中的G1/S停滞。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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