I0404
靛玉红-3′ -单肟
≥98% (HPLC), solid
别名:
靛玉红-3′-肟
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关于此项目
经验公式（希尔记法）:
C16H11N3O2
化学文摘社编号:
分子量:
277.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,17,21H,(H,18,20)/b15-13-,19-14+
SMILES string
O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4ccccc34
InChI key
HBDSHCUSXQATPO-BGBJRWHRSA-N
assay
≥98% (HPLC)
form
solid
mol wt
277.28
solubility
DMSO: >10 mg/mL, H2O: insoluble
storage temp.
room temp
Quality Level
Application
靛红-3′-肟已被用于抑制人单核细胞系THP-1中的糖原合酶激酶3。
Biochem/physiol Actions
靛红-3′-肟在Jurkat T细胞中可介导凋亡，并具有抗肿瘤功能。 靛红-3′-肟可抑制Y框结合蛋白1（YB1）的易位，有助于抗癌功能。 靛红-3′-肟可降低人神经母细胞瘤中雌激素相关受体γ (ERRγ)和过氧化物酶体增殖物激活的受体-γ 共激活因子-1α (PGC1α)的表达，从而导致细胞周期停滞和线粒体功能障碍。
靛红-3′-肟是一种细胞周期蛋白依赖性激酶抑制剂，可通过与ATP竞争结合催化亚基而发挥功能。其具有抗增殖活性，可导致许多细胞系中的G2/M停滞和Jurkat细胞中的G1/S停滞。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Semi-synthesis of indirubin-3′-oxime from Strobilanthes cusia leaves, its acute and sub-chronic toxicity, in vitro and in vivo antitumor activity in Lewis lung carcinoma bearing mice.
Cuong NM, et al.
Journal of Pharmacognosy and Phytochemistry, 5(4), 205-205 (2016)
Dynamic modulation of innate immune response by varying dosages of LPS in human monocytic cells.
Morris M, et al.
The Journal of Biological Chemistry, 289(31), 21584-21590 (2014)
Indirubin-3'-oxime induces mitochondrial dysfunction and triggers growth inhibition and cell cycle arrest in human neuroblastoma cells.
Liao XM and Leung KN
Oncology Reports, 29(1), 371-379 (2013)
Ming-Yang Lee et al.
European journal of pharmacology, 839, 57-65 (2018-09-30)
Cholangiocarcinoma (CCA) is one of the most serious of all cancers and a major public health problem. CCA is an extremely invasive cancer, and the survival rate for CCA patients is only 24 months after diagnosis. Although surgery and chemotherapy
Mechanism responsible for inhibitory effect of indirubin 3?-oxime on anticancer agent-induced YB-1 nuclear translocation in HepG2 human hepatocellular carcinoma cells.
Tanaka T, et al.
Experimental Cell Research, 370(2), 454-460 (2018)
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