I0779
Interleukin-2 Soluble Receptor α human
>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
别名:
CD25, IL-2 sRα, Tac antigen
产品名称
Interleukin-2 Soluble Receptor α human, >97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
biological source
human
recombinant
expressed in NSO cells
assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
0.5-1.0 mg per mL ED50
mol wt
36 kDa by SDS-PAGE
packaging
pkg of 5 μg
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... IL2RA(3559)
Analysis Note
The bioactivity is measured by its ability to inhibit the IL-2-dependent proliferation of a human megakaryocytic leukemic cell line, M07e.
Biochem/physiol Actions
Interleukin-2 (IL-2), a cytokine, enhances Th (T helper) cell differentiation and effector responses. In addition, it helps in immune tolerance. IL-2 binds to the high affinity receptor, formed of IL2RA (interleukin 2 receptor subunit α), IL2RB (interleukin 2 receptor subunit β) and γ-chain. Polymorphism in IL2RA is associated with multiple sclerosis. Null mutation in IL2RA results in immune dysregulation.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Kevin Goudy et al.
Clinical immunology (Orlando, Fla.), 146(3), 248-261 (2013-02-19)
Cell-surface CD25 expression is critical for maintaining immune function and homeostasis. As in few reported cases, CD25 deficiency manifests with severe autoimmune enteritis and viral infections. To dissect the underlying immunological mechanisms driving these symptoms, we analyzed the regulatory and
G C Avanzi et al.
British journal of haematology, 69(3), 359-366 (1988-07-01)
A new human leukaemic cell line (M-O7) with the phenotypic characteristics of CFU-mega is described. Its cells are positive for T200 leucocyte common antigen (LCA) and negative with MAbs recognizing T and B cells and mature myelomonocytic antigens. In contrast
Felix J Hartmann et al.
Nature communications, 5, 5056-5056 (2014-10-04)
Genome-wide association studies implicate dysregulation of immune mechanisms in the pathogenesis of multiple sclerosis (MS). Particularly, polymorphisms in genes involved in T helper (TH) cell differentiation are associated with risk of developing MS. However, the underlying mechanism by which these
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