I0782
Imazodan
≥99% (HPLC)
别名:
4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone, Cl 914
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关于此项目
经验公式（希尔记法）:
C13H12N4O
化学文摘社编号:
分子量:
240.26
UNSPSC Code:
41106305
PubChem Substance ID:
MDL number:
InChI
1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
SMILES string
O=C1CCC(=NN1)c2ccc(cc2)-n3ccnc3
InChI key
VXMYWVMXSWJFCV-UHFFFAOYSA-N
assay
≥99% (HPLC)
color
yellow, powder
solubility
DMSO: 50 mg/mL, clear, yellow
Gene Information
human ... PDE3A(5139)
rat ... Pde3a(50678)
Biochem/physiol Actions
Selective phoshodiesterase III (PDE3) inhibitor.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
[Phosphodiesterase inhibition as a new positive-inotropic principle].
A Hartmann et al.
Deutsche medizinische Wochenschrift (1946), 111(51-52), 1971-1977 (1986-12-19)
Determination of 4,5-dihydro-6-[4-(1H-imidazol-1-yl) phenyl]-3(2H)-pyridazinone hydrochloride, a new cardiotonic, in plasma and urine by reversed-phase high-performance liquid chromatography.
A G Hayes et al.
Journal of chromatography, 336(2), 446-451 (1984-12-12)
High-performance liquid chromatographic assay of imazodan, methylparaben and propylparaben in imazodan injection.
T Geria et al.
Journal of chromatography, 450(3), 407-413 (1988-10-26)
S E Sadler
Molecular endocrinology (Baltimore, Md.), 5(12), 1947-1954 (1991-12-01)
Insulin-like growth factor-I (IGF-I) stimulated Xenopus laevis oocyte ribosomal S6 kinase activity 5- to 10-fold, with an apparent EC50 of 0.8 +/- 0.1 nM after 90 min of hormone treatment. IGF-I-stimulated enzyme activity was inhibited by treatment of oocytes with
R P Steffen et al.
Journal of cardiovascular pharmacology, 8(3), 520-526 (1986-05-01)
The purpose of this study was to evaluate the effect of the new cardiotonic, imazodan (CI-914), on myocardial hemodynamics and oxygen consumption, and peripheral blood flow distribution. Organ blood flow was measured by the radiolabeled-microsphere-reference-withdrawal technique and myocardial oxygen consumption
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