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Merck
CN

I0899

丙米嗪 盐酸盐

BioXtra, ≥99% (TLC)

别名:

10,11-二氢-N，N-二甲基-5H-苯并[b，f]氮杂卓-5-丙胺 盐酸盐, 5-[3-(二甲基氨基)丙基]-10,11-二氢-5H-苯并[b，f] 氮杂卓 盐酸盐

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关于此项目

经验公式（希尔记法）:
C19H24N2 · HCl
化学文摘社编号:
113-52-0
分子量:
316.87
NACRES:
NA.25
PubChem Substance ID:
24895912
UNSPSC Code:
12352116
EC Number:
204-030-7
MDL number:
MFCD00012669

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产品名称

丙米嗪 盐酸盐, BioXtra, ≥99% (TLC)

InChI key

XZZXIYZZBJDEEP-UHFFFAOYSA-N

InChI

1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H

SMILES string

Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13

product line

BioXtra

assay

≥99% (TLC)

form

powder

impurities

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

ign. residue

≤0.1%

solubility

H2O: 50 mg/mL, colorless to faintly yellow

anion traces

sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.005%
Cu: ≤0.0005%
Fe: ≤0.005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

Quality Level

200

Gene Information

human ... SLC6A2(6530), SLC6A4(6532)

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相关类别

Application


  • 基于O端原始纳米晶掺硼金刚石电极的新颖、快速、可靠的电化学dsDNA生物传感器，适用于DNA相互作用研究。：该研究的特点是新型电化学dsDNA生物传感器有助于研究DNA与盐酸丙咪嗪的相互作用，从而加深我们对其基因毒性效应的了解，并为生物化学应用提供重要的启示（Augustín M et al., 2024）。

  • 比较两种诱导驴体外射精的药理方案。：在这项比较研究中，盐酸丙咪嗪被用于药理学方案中，为兽医应用和动物生殖研究提供了重要见解（Khan FA et al., 2024）。

  • 基于与对苯醌形成分子络合物的三环抗抑郁药可见分光光度测定方法的开发。：该出版物概述了分析盐酸丙咪嗪等三环抗抑郁药的新型分光光度法，为制药和临床研究中的定量分析提供了有效工具（Ciuca MD et al., 2023）。

Biochem/physiol Actions

三环类抗抑郁药；抑制 5-羟色胺和去甲肾上腺素转运蛋白；对多巴胺转运蛋白影响很小。
三环类抗抑郁药；抑制血清素和去甲肾上腺素转运蛋白的 Ki 值分别为 7.7 nM 和 67 nM。对多巴胺转运蛋白影响很小（Ki = 25 μM）。

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000503902
0000503902
0000422892
0000422892
0000317033

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