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安全信息

I1020

Sigma-Aldrich

Interleukin-4 from mouse

IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

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别名:
mIL-4, Interleukin-4 human
MDL编号:
MFCD00166698
NACRES:
NA.77

生物来源

mouse

重组

expressed in E. coli

检测方案

≥98% (SDS-PAGE)

形式

lyophilized powder

效能

0.1-2.0 ng/mL ED50/EC50

质量

endotoxin tested

分子量

~13.5 kDa

包装

pkg of 5 μg

技术

cell culture | mammalian: suitable

杂质

<0.1 EU/μg

UniProt登记号

P07750

储存温度

−20°C

基因信息

mouse ... Il4(16189)

相关类别

应用

Interleukin-4 from mouse has been used:
  • as a component of cell culture media for class switch recombination assay
  • to study its therapeutic benefits for mucosal healing
  • as a pioglitazone or new peroxisome proliferator-activated receptor agonist (GQ-11)

生化/生理作用

Interleukin-4 (IL-4) is a lymphokine with profound effects on the growth and differentiation of immunologically competent cells. IL-4 is also known as B cell stimulatory factor-1 (BSF-1), T cell growth factor-2 (TCGF-2) and mast-cell growth factor-2 (MCGF-2). Inhibits VEGF-induced and FGF-Basic-induced angiogenesis. IL-4 is a complex glycoprotein released by a subset of activated T cells. Treatment of IL-4 with specific glycosidases yields an active polypeptide. Human and mouse IL-4 share 50% amino acid sequence homology, but their biological actions are species-specific.

外形

Lyophilized, 0.2 μm filtered, with no additives.

分析说明

The proliferative activity is tested in culture using mouse HT-2 cells.

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

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Commodore P St Germain et al.
Nucleic acids research, 50(4), 2051-2073 (2022-02-01)
Conflicts between transcription and replication machinery are a potent source of replication stress and genome instability; however, no technique currently exists to identify endogenous genomic locations prone to transcription-replication interactions. Here, we report a novel method to identify genomic loci
Interleukin 4 induces rapid mucin transport, increases mucus thickness and quality and decreases colitis and Citrobacter rodentium in contact with epithelial cells
Sharba S, et al.
Virulence, 10(1), 97-117 (2019)
VX-984 is a selective inhibitor of non-homologous end joining, with possible preferential activity in transformed cells
Khan AJ, et al.
Oncotarget, 9(40), 25833-25833 (2018)
R Fernandez-Botran et al.
The Journal of experimental medicine, 164(2), 580-593 (1986-08-01)
T cell-derived supernatants (SN) that contain B cell-stimulatory factor 1 (BSF-1) and lack IL-2 promote the growth of the IL-2-dependent T cell line, HT-2, as well as three other clones or lines of T cells that can provide help to
New Peroxisome Proliferator-Activated Receptor Agonist (GQ-11) Improves Wound Healing in Diabetic Mice
Silva JC, et al.
Advances in Wound Care (2019)
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