I1020
IL-4 mouse
≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
别名:
Interleukin-4, mIL-4, Interleukin-4 human
产品名称
Interleukin-4 from mouse, IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
biological source
mouse
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE)
form
lyophilized powder
potency
0.1-2.0 ng/mL ED50/EC50
quality
endotoxin tested
mol wt
~13.5 kDa
packaging
pkg of 5 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Il4(16189)
Analysis Note
The proliferative activity is tested in culture using mouse HT-2 cells.
Application
Interleukin-4 from mouse has been used:
- as a component of cell culture media for class switch recombination assay
- to study its therapeutic benefits for mucosal healing
- as a pioglitazone or new peroxisome proliferator-activated receptor agonist (GQ-11)
Biochem/physiol Actions
Interleukin-4 (IL-4) is a lymphokine with profound effects on the growth and differentiation of immunologically competent cells. IL-4 is also known as B cell stimulatory factor-1 (BSF-1), T cell growth factor-2 (TCGF-2) and mast-cell growth factor-2 (MCGF-2). Inhibits VEGF-induced and FGF-Basic-induced angiogenesis. IL-4 is a complex glycoprotein released by a subset of activated T cells. Treatment of IL-4 with specific glycosidases yields an active polypeptide. Human and mouse IL-4 share 50% amino acid sequence homology, but their biological actions are species-specific.
Interleukin-4, a lymphokine with profound effects on the growth and differentiation of immunologically competent cells, inhibits VEGF-induced and bFGF-induced angiogenesis. Human and mouse IL-4 share 50% amino acid sequence identity, but their biological actions are species-specific.
Physical form
Lyophilized, 0.2 μm filtered, with no additives.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
New Peroxisome Proliferator-Activated Receptor Agonist (GQ-11) Improves Wound Healing in Diabetic Mice
Silva JC, et al.
Advances in Wound Care (2019)
R Fernandez-Botran et al.
The Journal of experimental medicine, 164(2), 580-593 (1986-08-01)
T cell-derived supernatants (SN) that contain B cell-stimulatory factor 1 (BSF-1) and lack IL-2 promote the growth of the IL-2-dependent T cell line, HT-2, as well as three other clones or lines of T cells that can provide help to
Interleukin 4 induces rapid mucin transport, increases mucus thickness and quality and decreases colitis and Citrobacter rodentium in contact with epithelial cells
Sharba S, et al.
Virulence, 10(1), 97-117 (2019)
VX-984 is a selective inhibitor of non-homologous end joining, with possible preferential activity in transformed cells
Khan AJ, et al.
Oncotarget, 9(40), 25833-25833 (2018)
Commodore P St Germain et al.
Nucleic acids research, 50(4), 2051-2073 (2022-02-01)
Conflicts between transcription and replication machinery are a potent source of replication stress and genome instability; however, no technique currently exists to identify endogenous genomic locations prone to transcription-replication interactions. Here, we report a novel method to identify genomic loci
商品
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
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