I117
R(+)-IAA-94
≥98% (HPLC), chloride ion channel inhibitor, solid
别名:
R(+)-[(6,7-二氯-2-环戊基-2,3-二氢-2-甲基-1-氧代-1H-茚满-5-基)-氧]乙酸, R(+)-甲基吲唑酮, 茚满基含氧乙酸 94
Product Name
R(+)-IAA-94, ≥98% (HPLC), solid
质量水平
方案
≥98% (HPLC)
表单
solid
旋光性
[α]22/D +36.4°, c = 0.86 in methanol(lit.)
颜色
white
溶解性
H2O: 0.2 mg/mL
0.1 M NaOH: 2.8 mg/mL
DMSO: >20 mg/mL
ethanol: 20 mg/mL
dilute aqueous acid: insoluble
储存温度
2-8°C
SMILES字符串
C[C@@]1(Cc2cc(OCC(O)=O)c(Cl)c(Cl)c2C1=O)C3CCCC3
InChI
1S/C17H18Cl2O4/c1-17(10-4-2-3-5-10)7-9-6-11(23-8-12(20)21)14(18)15(19)13(9)16(17)22/h6,10H,2-5,7-8H2,1H3,(H,20,21)/t17-/m1/s1
InChI key
RNOJGTHBMJBOSP-QGZVFWFLSA-N
相关类别
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Roberto J Diaz et al.
Cardiovascular research, 87(3), 545-551 (2010-03-17)
We have previously shown that reduction of ischaemic cell swelling via enhanced cell volume regulation is a key mechanism of ischaemic preconditioning (IPC) in cardiomyocytes. We have also shown that pharmacological blockade of Cl(-) channels abolishes cardioprotection achieved by IPC
D M Briggs Boedtkjer et al.
Pflugers Archiv : European journal of physiology, 457(2), 389-404 (2008-06-10)
The possibility that Ca(2+)-activated Cl(-) conductances (CaCCs) contribute to oscillations in vascular tone (vasomotion) is tested in isolated mesenteric small arteries from rats where cGMP independent (I (Cl(Ca))) and cGMP-dependent (I (Cl(Ca,cGMP))) chloride conductances are important. The effect of anion
Federica Barbieri et al.
Frontiers in pharmacology, 9, 899-899 (2018-09-07)
The antidiabetic biguanide metformin exerts antiproliferative effects in different solid tumors. However, during preclinical studies, metformin concentrations required to induce cell growth arrest were invariably within the mM range, thus difficult to translate in a clinical setting. Consequently, the search
Influence of T-type Ca2+ (mibefradil) and Cl- (indanyloxyacetic acid 94) channel antagonists on ?1-adrenoceptor mediated contractions in rat aorta.
Duggan AJ and Tabrizchi R
Canadian Journal of Physiology and Pharmacology, 78(9), 714-720 (2000)
Disposition and intracellular levels of moxifloxacin in human THP-1 monocytes in unstimulated and stimulated conditions
Hall I H, et al.
International Journal of Antimicrobial Agents, 22(6), 579-587 (2003)
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