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I117

R(+)-IAA-94

Name: R(+)-IAA-94
Brand: SIGMA

≥98% (HPLC), chloride ion channel inhibitor, solid

别名:

R(+)-[(6,7-二氯-2-环戊基-2,3-二氢-2-甲基-1-氧代-1H-茚满-5-基)-氧]乙酸, R(+)-甲基吲唑酮, 茚满基含氧乙酸 94

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₈Cl₂O₄

化学文摘社编号:

54197-31-8

分子量:

357.23

UNSPSC Code:

12352200

PubChem Substance ID:

24277844

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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属性

产品名称

R(+)-IAA-94, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

optical activity

[α]22/D +36.4°, c = 0.86 in methanol(lit.)

color

white

solubility

H₂O: 0.2 mg/mL, 0.1 M NaOH: 2.8 mg/mL, DMSO: >20 mg/mL, ethanol: 20 mg/mL, dilute aqueous acid: insoluble

storage temp.

2-8°C

SMILES string

C[C@@]1(Cc2cc(OCC(O)=O)c(Cl)c(Cl)c2C1=O)C3CCCC3

InChI

1S/C17H18Cl2O4/c1-17(10-4-2-3-5-10)7-9-6-11(23-8-12(20)21)14(18)15(19)13(9)16(17)22/h6,10H,2-5,7-8H2,1H3,(H,20,21)/t17-/m1/s1

InChI key

RNOJGTHBMJBOSP-QGZVFWFLSA-N

说明

Application

R(+)-IAA-94已被用作氯离子通道抑制剂，用于研究其对人单核（THP-1）细胞摄取格氟沙星的影响。它还被用作氯离子通道抑制剂，用于研究其对人单核（THP-1）细胞摄取莫西沙星的影响。

Features and Benefits

该化合物在受体分类和信号转导手册的氯化物通道页面上有重点介绍。想要浏览手册的其他页面，请单击此处。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000530189

0000530187

0000494146

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Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition.

Michelle Batthish et al.

Cardiovascular research, 55(3), 660-671 (2002-08-06)

We have recently proposed that chloride (Cl(-)) channels contribute to ischemic preconditioning (IPC) in the myocardium. To further evaluate this hypothesis, we investigated the role of Cl(-) channels in pharmacological preconditioning. Isolated rabbit cardiomyocytes and isolated buffer-perfused rabbit hearts were

Influence of T-type Ca2+ (mibefradil) and Cl- (indanyloxyacetic acid 94) channel antagonists on ?1-adrenoceptor mediated contractions in rat aorta.

Duggan AJ and Tabrizchi R

Canadian Journal of Physiology and Pharmacology, 78(9), 714-720 (2000)

Disposition and intracellular levels of moxifloxacin in human THP-1 monocytes in unstimulated and stimulated conditions

Hall I H, et al.

International Journal of Antimicrobial Agents, 22(6), 579-587 (2003)

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货号	GTIN
I117-50MG-I	04061832574646
I117-250MG-I	04061832574639
I117-10MG-I	04061832574622