I127
ICI 118,551 盐酸盐
≥98% (HPLC), powder, β2 inverse agonist
别名:
(2R,3R)-rel-3-异丙胺-1-（7-甲基吲哚-4-氧基）-丁-2-醇 盐酸盐
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关于此项目
经验公式（希尔记法）:
C17H27NO2 · HCl
化学文摘社编号:
分子量:
313.86
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
ICI 118,551 盐酸盐, ≥98% (HPLC), powder
SMILES string
Cl.CC(C)N[C@@H](C)[C@@H](O)COc1ccc(C)c2CCCc12
InChI
1S/C17H27NO2.ClH/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17;/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3;1H/t13-,16-;/m0./s1
InChI key
KBXMBGWSOLBOQM-LINSIKMZSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
H2O: >10 mg/mL
Quality Level
Gene Information
human ... ADRB2(154)
相关类别
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
R M Booze et al.
The Journal of pharmacology and experimental therapeutics, 249(3), 911-920 (1989-06-01)
The localization and number of beta adrenergic receptors were directly compared in the brains of rats and guinea pigs. The time course of association and saturability of [125I]cyanopindolol (CYP) binding to slide-mounted tissue sections was similar in rats (Kd =
Hongliang Li et al.
The Journal of biological chemistry, 288(42), 30734-30741 (2013-09-18)
Functional autoantibodies to the autonomic receptors are increasingly recognized in the pathophysiology of cardiovascular diseases. To date, no human activating monoclonal autoantibodies to these receptors have been available. In this study, we describe for the first time a β2-adrenergic receptor
Analysis of ICI 118551, a new beta2 blocking drug, and related compounds by RP-HPLC?DAD
Quaglia MG, et al.
Journal of Pharmaceutical and Biomedical Analysis, 10(10-12), 1081-1084 (1992)
beta-Adrenergic-stimulated macrophages: comprehensive localization in the M1-M2 spectrum
Lamkin DM, et al.
Brain, behavior, and immunity, 57(, 338-346 (2016)
A J Bilski et al.
Journal of cardiovascular pharmacology, 5(3), 430-437 (1983-05-01)
While specific antagonists of the beta 1-adrenoceptor, such as atenolol and betaxolol, are widely available, a potent specific antagonist selective for the beta 2-adrenoceptor has yet to be described. Previously described beta 2-selective antagonists such as butoxamine, H 35/25, and
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