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产品名称
白介素 -6 人, IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
生物来源
human
质量水平
重组
expressed in E. coli
方案
≥97% (SDS-PAGE)
表单
lyophilized powder
效能
0.2-2.0 ng/mL ED50/EC50
质量
endotoxin tested
分子量
26 kDa
包装
pkg of 10 and 50 μg
储存条件
avoid repeated freeze/thaw cycles
技术
cell culture | mammalian: suitable
杂质
≤1.000 EU/μg
颜色
white
UniProt登记号
储存温度
−20°C
基因信息
human ... IL6(3569)
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相关类别
生化/生理作用
白细胞介素-6 (IL-6) 是最初在双链 RNA 刺激的细胞培养基中发现的一种多功能蛋白。IL-6 似乎直接参与了感染和损伤后发生的反应，并可能证明在调节急性期反应方面与 IL-1 和 TNF-α 同样重要。据报道，IL-6 由成纤维细胞、活化的 T 细胞、活化的单核细胞或巨噬细胞以及内皮细胞产生。作用于多种细胞，包括成纤维细胞、髓系祖细胞、T 细胞、B 细胞和肝细胞。如许多同义词所示，IL-6 诱导多种效应：浆细胞瘤生长因子 (PCT-GF)、干扰素-β-2（IFN-β 2 ）、单核细胞来源的人 B 细胞生长因子、B 细胞刺激因子 (BSF-2)、肝细胞刺激因子 (HSF)、白细胞介素杂交瘤/浆细胞瘤-1 (IL-HP1)。此外，IL-6 似乎在 T 淋巴细胞增殖中与 IL-2 相互作用。IL-6 还可增强 IL-3 对多潜能造血祖细胞的增殖作用。
外形
从含有 500 μg 牛血清白蛋白的 0.2 μm 磷酸盐缓冲液 (PBS) (pH 7.4) 过滤溶液冻干。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Maria Ferraiuolo et al.
Cancer letters, 433, 18-32 (2018-06-23)
Osteosarcoma (OS) is the most aggressive type of primary solid tumor that develops in bone. Whilst conventional chemotherapy can improve survival rates, the outcome for patients with metastatic or recurrent OS remains poor, so novel treatment agents and strategies are
Jee Eun Choi et al.
STAR protocols, 3(2), 101389-101389 (2022-05-24)
Metabolic reprogramming is associated with myeloid-derived suppressor cell (MDSC) immunosuppressive function. Here, we outline the process for acquiring MDSCs from human and murine sources for subsequent analysis of fatty acid oxidation, oxidative phosphorylation, and glycolysis using the Seahorse XFe 96
Hemn Mohammadpour et al.
Cell reports, 37(4), 109883-109883 (2021-10-28)
Myeloid-derived suppressor cells (MDSCs) impede antitumor immunity; however, the precise mechanisms that regulate their suppressive function remain unresolved. Identifying these mechanisms could lead to therapeutic interventions to boost cancer immunotherapy efficacy. Here, we reveal that β2 adrenergic receptor (β2-AR) expression
Adriana Catalli et al.
PloS one, 9(5), e96891-e96891 (2014-05-14)
Despite the fact that glucocorticoids and long acting beta agonists are effective treatments for asthma, their effects on human mast cells (MC) appear to be modest. Although MC are one of the major effector cells in the underlying inflammatory reactions
Bin Zhang et al.
Stem cells and development, 23(11), 1233-1244 (2013-12-26)
Mesenchymal stem cells (MSCs) have been shown to secrete exosomes that are cardioprotective. Here, we demonstrated that MSC exosome, a secreted membrane vesicle, is immunologically active. MSC exosomes induced polymyxin-resistant, MYD88-dependent secreted embryonic alkaline phosphatase (SEAP) expression in a THP1-Xblue
商品
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
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