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I145

I-AB-MECA

solid

别名:

1-[6-[[(4-Amino-3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofuranuronamide, 3-Iodo-4-aminobenzyl-5′-N-methylcarboxamidoadenosine, N6-(4-Amino-3-iodobenzyl)-5′-N-methylcarbamoyladenosine

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关于此项目

经验公式（希尔记法）:
C18H20IN7O4
化学文摘社编号:
152918-27-9
分子量:
525.30
NACRES:
NA.77
PubChem Substance ID:
24895933
UNSPSC Code:
12352200
MDL number:
MFCD00671784
Form:
solid
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form

solid

color

off-white

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL, DMSO: 10 mg/mL, 0.1 M NaOH: 2 mg/mL, 0.1 M HCl: 7 mg/mL, H2O: insoluble

storage temp.

−20°C

SMILES string

CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NCc4ccc(N)c(I)c4)ncnc23

InChI

1S/C18H20IN7O4/c1-21-17(29)14-12(27)13(28)18(30-14)26-7-25-11-15(23-6-24-16(11)26)22-5-8-2-3-10(20)9(19)4-8/h2-4,6-7,12-14,18,27-28H,5,20H2,1H3,(H,21,29)(H,22,23,24)/t12-,13+,14-,18+/m0/s1

InChI key

LOGOEBMHHXYBID-MOROJQBDSA-N

Gene Information

human ... ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

Biochem/physiol Actions

Reference standard for radioiodinated I-AB-MECA, a widely used, high affinity radioligand for the A3 adenosine receptor.

Legal Information

Sold under license from the National Institutes of Health.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
048H4644

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M E Olah et al.
Molecular pharmacology, 45(5), 978-982 (1994-05-01)
The rat A3 adenosine receptor (AR) is a recently characterized AR subtype cloned from testis and brain cDNA libraries. N6-2-(4-Amino-3-[125I]iodophenyl)ethyladenosine, a high affinity A1AR agonist, has served as the only radioligand available for study of the A3AR. The relatively low
D K Von Lubitz et al.
European journal of pharmacology, 275(1), 23-29 (1995-02-24)
We have previously shown that acute preischemic adenosine A3 receptor stimulation results in an increased postischemic damage, while chronic stimulation of this receptor diminishes it. Since several pathophysiological phenomena are common for both ischemia and seizures, we have explored the
K A Jacobson et al.
FEBS letters, 336(1), 57-60 (1993-12-20)
The behavioral effects of a selective A3 adenosine receptor agonist 3-IB-MECA (N6-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine) in mice and the localization of radioligand binding sites in mouse brain were examined. Low levels of A3 adenosine receptors were detected in various regions of the mouse

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货号GTIN
I145-5MG04061832271859
I145-1MG04061825982335