I1637
Ipratropium bromide monohydrate
≥98% (TLC), powder
别名:
Atropine isopropyl bromide
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关于此项目
经验公式（希尔记法）:
C20H30BrNO3 · H2O
化学文摘社编号:
分子量:
430.38
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
244-873-8
MDL number:
InChI key
KEWHKYJURDBRMN-XSAPEOHZSA-M
InChI
1S/C20H30NO3.BrH.H2O/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15;;/h4-8,14,16-19,22H,9-13H2,1-3H3;1H;1H2/q+1;;/p-1/t16-,17+,18+,19?,21?;;
SMILES string
O.[Br-].CC(C)[N@+]1(C)[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3
assay
≥98% (TLC)
form
powder
color
white
solubility
H2O: 10 mg/mL
originator
Boehringer Ingelheim
Quality Level
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
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Application
Ipratropium bromide monohydrate has been used for the inhibition of peripheral muscarinic receptors in rats.
Biochem/physiol Actions
Ipratropium bromide monohydrate is a nonselective muscarinic acetylcholine receptor antagonist and a bronchodilator. In nebulized form, it is used for treating asthma and obstructive pulmonary diseases. It acts as a β2 adrenoreceptor agonist. Ipratropium bromide monohydrate is an anticholinergic agent and competes with acetylcholine. It promotes bronchodilation by stimulating sympathetic pathways.
Features and Benefits
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Other Notes
N-isopropyl quaternary salt of atropine.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 2
法规信息
新产品
此项目有
P J Barnes
Chest, 117(2 Suppl), 63S-66S (2000-02-16)
Tiotropium is a long-acting anticholinergic drug. Studies with cloned human muscarinic receptors show that tiotropium binds equally well to M(1), M(2), and M(3) receptors. However, it dissociates very slowly from M(1) and M(3) receptors compared with ipratropium, and more rapidly
E B Haddad et al.
British journal of pharmacology, 127(2), 413-420 (1999-06-29)
1. In this study we have evaluated the pharmacological profile of the muscarinic antagonist glycopyrrolate in guinea-pig and human airways in comparison with the commonly used antagonist ipratropium bromide. 2. Glycopyrrolate and ipratropium bromide inhibited EFS-induced contraction of guinea-pig trachea
Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrrolate.
Ogoda M, et al.
Journal of Pharmacological Sciences, 115(3), 374-382 (2011)
For COPD a combination of ipratropium bromide and albuterol sulfate is more effective than albuterol base.
Campbell S
Archives of Internal Medicine, 159(2), 156-160 (1999)
H Groeben et al.
Anesthesiology, 85(4), 867-873 (1996-10-01)
Two major groups of drugs are available to prevent bronchoconstriction: beta-agonists and muscarinic blocking agents. Ipratropium is the most commonly used anticholinergic agent to treat chronic obstructive pulmonary disease. The authors studied anti-muscarinic agents to determine if they are as
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