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I1637

Ipratropium bromide monohydrate

Name: Ipratropium bromide monohydrate
Brand: SIGMA

≥98% (TLC), powder

别名:

Atropine isopropyl bromide

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关于此项目

经验公式（希尔记法）:

C₂₀H₃₀BrNO₃· H₂O

化学文摘社编号:

66985-17-9

分子量:

430.38

NACRES:

NA.77

PubChem Substance ID:

24277843

UNSPSC Code:

12352200

EC Number:

244-873-8

MDL number:

MFCD00792907

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

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Quality Level

200

assay

≥98% (TLC)

form

powder

color

white

solubility

H₂O: 10 mg/mL

originator

Boehringer Ingelheim

SMILES string

O.[Br-].CC(C)[N@+]1(C)[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3

InChI

1S/C20H30NO3.BrH.H2O/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15;;/h4-8,14,16-19,22H,9-13H2,1-3H3;1H;1H2/q+1;;/p-1/t16-,17+,18+,19?,21?;;

InChI key

KEWHKYJURDBRMN-XSAPEOHZSA-M

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Application

Ipratropium bromide monohydrate has been used for the inhibition of peripheral muscarinic receptors in rats.

Biochem/physiol Actions

Ipratropium bromide monohydrate is a nonselective muscarinic acetylcholine receptor antagonist and a bronchodilator. In nebulized form, it is used for treating asthma and obstructive pulmonary diseases. It acts as a β₂ adrenoreceptor agonist. Ipratropium bromide monohydrate is an anticholinergic agent and competes with acetylcholine. It promotes bronchodilation by stimulating sympathetic pathways.

Features and Benefits

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

N-isopropyl quaternary salt of atropine.

pictograms

GHS07

signalword

Warning

hcodes

H302 + H332,H319

pcodes

P261 - P264 - P271 - P301 + P312 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 2

法规信息

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Pharmacological characterization of the muscarinic receptor antagonist, glycopyrrolate, in human and guinea-pig airways.

E B Haddad et al.

British journal of pharmacology, 127(2), 413-420 (1999-06-29)

1. In this study we have evaluated the pharmacological profile of the muscarinic antagonist glycopyrrolate in guinea-pig and human airways in comparison with the commonly used antagonist ipratropium bromide. 2. Glycopyrrolate and ipratropium bromide inhibited EFS-induced contraction of guinea-pig trachea

For COPD a combination of ipratropium bromide and albuterol sulfate is more effective than albuterol base.

Campbell S

Archives of Internal Medicine, 159(2), 156-160 (1999)

Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrrolate.

Ogoda M, et al.

Journal of Pharmacological Sciences, 115(3), 374-382 (2011)

The pharmacological properties of tiotropium.

P J Barnes

Chest, 117(2 Suppl), 63S-66S (2000-02-16)

Tiotropium is a long-acting anticholinergic drug. Studies with cloned human muscarinic receptors show that tiotropium binds equally well to M(1), M(2), and M(3) receptors. However, it dissociates very slowly from M(1) and M(3) receptors compared with ipratropium, and more rapidly

Bilateral acute angle closure developing due to use of ipratropium bromide and salbutamol.

Kola M, et al.

International Ophthalmology, 38(1), 385-388 (2018)

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货号	GTIN
I1637-1G	04061833847893
I1637-250MG	04061833847909

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