应用
白细胞介素-8 (IL-8) 用于：
- 测量中性粒细胞化学毒性
- 脑膜上皮细胞摄取凋亡细胞的研究
- IL-8 对人脐静脉内皮细胞表达和分泌尿促皮素-1 的影响
生化/生理作用
白细胞介素-8 (IL-8) 以往称为单核细胞衍生的中性粒细胞趋化因子，属于趋化因子 αC-X-C 家族。IL-8 的成熟形式有 4 个半胱氨酸残基，趋化因子家族的其他成员也是如此，前两个半胱氨酸残基被谷氨酰胺分开。成熟人 IL-8 由 72 个氨基酸组成，分子量为 8.4 kDa。IL-8 在体外 对 T 细胞、嗜碱性粒细胞表现出趋化活性 ，通过酶包括髓过氧化物酶、α-甘露糖苷酶和 β-葡萄糖醛酸酶。IL-8 是一种血管生成因子。
白细胞介素-8 (IL-8) 原称单核细胞源性中性粒细胞趋化因子。属于趋化因子 αC-X-C 家族。与该家族的其他成员一样，IL-8 的成熟形式有 4 个半胱氨酸残基，前 2 个半胱氨酸残基被谷氨酰胺分开。IL-8 在体外 对 T 细胞、中性粒细胞和嗜碱粒细胞具有趋化活性 。IL-8 基因突变可增加急性胰腺炎的发病风险。
外形
从 0.2 μm 冻干m 过滤溶液，无添加剂。
分析说明
生物活性取决于其化学吸引人外周血中性粒细胞的能力，浓度范围为 10.0-100.0 ng/mL。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
X B Bao et al.
Genetics and molecular research : GMR, 14(1), 1508-1514 (2015-03-03)
We conducted a case-control study to clarify the asso-ciations between inflammatory cytokine, including interleukin (IL)-1b, IL-6, IL-8, and IL-10, polymorphisms and risk of acute pancreatitis. Genotyping analyses of IL-1β+3954 C/T (rs1143634), IL-1β-511 C/T (rs16944), IL-6 -174 G/C (rs1800795), IL-6 -634
M V White et al.
Immunology letters, 22(2), 151-154 (1989-08-01)
Basophils from five of six human donors released histamine in response to neutrophil attractant/activation protein-1 (NAP-1). Histamine release by this protein was concentration-dependent over the range of 3 x 10(-7) M to 4 x 10(-6) M. At 4 x 10(-6)
Eugene L Bek et al.
Clinical science (London, England : 1979), 103 Suppl 48, 424S-429S (2002-08-24)
In diabetes mellitus, there is a problem of both premature atherosclerosis as well as impaired collateralization. Studies were performed using the rat corneal angiogenesis model as a surrogate for collateralization to determine the effect of diabetes mellitus on endothelin (ET)-1
Hyesol Lim et al.
Journal of cellular physiology, 236(10), 7014-7032 (2021-03-23)
Cancer-associated fibroblasts (CAFs) in the tumor microenvironment have been associated with tumor progression in breast cancer. Although crosstalk between breast cancer cells and CAFs has been studied, the effect of CAFs on non-neoplastic breast epithelial cells is not fully understood
D E Graugnard et al.
Journal of dairy science, 95(4), 1749-1758 (2012-03-31)
Cows experience some degree of negative energy balance and immunosuppression around parturition, making them vulnerable to metabolic and infectious diseases. The effect of prepartum feeding of diets to meet (control, 1.34 Mcal/kg of dry matter) or exceed (overfed, 1.62 Mcal/kg
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