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生物来源
human
质量水平
重组
expressed in E. coli
方案
≥97% (SDS-PAGE)
表单
lyophilized powder
效能
<10.000 ng/mL ED50
分子量
12 kDa
包装
pkg of 10 μg
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
1 of 4
此商品 | 271748 | P6155 | P9130 |
|---|---|---|---|
| biological source synthetic | biological source synthetic (Organic) | biological source - | biological source synthetic (organic) |
| assay ≥99.5% (T) | assay 99% | assay ≥99% (HPLC) | assay ≥99% (HPLC) |
| form powder | form powder | form powder | form powder |
| application(s) cell analysis | application(s) - | application(s) - | application(s) - |
| color white to faint beige | color white to off-white | color white to off-white | color white to off-white |
| mp 173 °C (dec.) (lit.) | mp 173 °C (dec.) (lit.) | mp 173 °C (dec.) (lit.) | mp 173 °C (dec.) (lit.) |
生化/生理作用
IL-13 is known to be overexpressed in glioblastoma tumors and cell lines.[1] Elevated IL-13 expression is also observed in parasitic infections.[2] It stimulates fibrosis in many infectious diseases,[3] and acts as a profibrogenic factor.[2]
Interleukin-13 is a pleiotropic cytokine produced by activated Th2 cells in the mouse and human. IL-13 is secreted mainly as an unglycosylated protein of 132 amino acids with a molecular weight of 10,000 daltons. A 4.3kb DNA fragment of the mouse IL-13 gene was sequenced and occurs as a single copy mapping a chromosome 11. In the human, a 4.6 kb DNA segment of the IL-13 gene occurs as a single copy and maps to chromosome 5. IL-13 induces B cell proliferation and also induces IgE switching. The proliferative activity of human and mouse IL-13 products are tested in culture using the human erythroleukemic cell line TF-1.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 250 μg BSA.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Electrophysiological and functional effects of the KCNQ channel blocker XE991 on murine portal vein smooth muscle cells
Yeung SYM and Greenwood IA
British Journal of Pharmacology, 146(4), 585-595 (2005)
Membrane-delimited inhibition of maxi-K channel activity by the intermediate conductance Ca2+-activated K channel
Thompson J and Begenisich T
The Journal of General Physiology, 127(2), 159-169 (2006)
Conservation of lipid metabolic gene transcriptional regulatory networks in fish and mammals
Carmona-Antonanzas, Greta and Tocher, Douglas R and Martinez-Rubio, Laura and Leaver, Michael J
Gene, 534(1), 1-9 (2014)
Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism
Zhou Y and Lingle CJ
The Journal of General Physiology, 144(5), 415-440 (2014)
Contribution of the functional coupling between the human myometrial beta2-adrenoreceptor and the BKCa channel to uterine quiescence
Chanrachakul B, et al.
American Journal of Physiology. Cell Physiology, 287(C1747?C1752), 585-595 (2004)
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