I1774
伊枯草菌素A 来源于枯草芽孢杆菌
≥95% (HPLC), suitable for microbiological culture
产品名称
伊枯草菌素A 来源于枯草芽孢杆菌, ≥95% (HPLC)
biological source
Bacillus subtilis
assay
≥95% (HPLC)
form
powder
technique(s)
microbiological culture: suitable
color
white to yellow
solubility
ethanol: soluble 9.80-10.20 mg/mL
antibiotic activity spectrum
fungi
mode of action
cell membrane | interferes
storage temp.
2-8°C
Quality Level
Application
伊枯草菌素A 用于 Bacillomycin D（一种具有抗黄曲霉抗真菌活性的 伊枯草菌素）的研究
Biochem/physiol Actions
伊枯草菌素A 对致病性酵母和真菌有很强的抗真菌活性。它与靶细胞的细胞质膜相互作用，形成离子传导孔。其作用方式可归因于其与固醇和磷脂的相互作用。该化合物导致人红细胞释放外囊泡（exo-vesicle）。
Other Notes
一个脂肽家族，其特征在于以C13-C17 β氨基脂肪酸环化的七肽。主要由C14-C15 β氨基酸组成。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Scott W Pryor et al.
Journal of agricultural and food chemistry, 55(23), 9530-9536 (2007-10-24)
Partial least squares (PLS) regression modeling was used to relate the antifungal activity of Bacillus subtilis solid-state fermentation extracts to the individual high-performance liquid chromatography (HPLC) peaks from those extracts. A model was developed that predicted bioassay inhibition based on
R Maget-Dana et al.
Toxicology, 87(1-3), 151-174 (1994-02-28)
Iturins are a family of lipopeptides extracted from the culture media of various strains of Bacillus subtilis. These amphiphilic compounds are characterized by a peptide ring of seven amino acid residues including an invariable D-Tyr2, with the constant chiral sequence
Nopporn Thasana et al.
FEBS letters, 584(14), 3209-3214 (2010-06-15)
Subtulene A, a new cyclic lipopeptide, was isolated from the culture broth of Bacillus subtilis SSE4. This antibiotic compound contained the seven common alpha-amino acids, L-Asn-1, D-Tyr-2, D-Asn-3, L-Gln-4, L-Pro-5, D-Asn-6, L-Ser-7 and the unique beta-amino acid-8 present in the
Thimon, L., et al.
Cytobios, 79, 96-96 (1994)
M A Klich et al.
Mycopathologia, 127(2), 123-127 (1994-08-01)
The removal of many synthetic fungicides from the market has created a demand for new, environmentally safe fungicides. Iturin A, a cyclic lipopeptide produced by Bacillus subtilis, has strong antifungal properties and low mammalian toxicity. To determine the efficacy of
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