I1786
ID-8
≥98% (HPLC)
别名:
1-（4-甲氧苯基）-2-甲基-3-硝基-1H-吲哚-6-醇
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C16H14N2O4
化学文摘社编号:
分子量:
298.29
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
SMILES string
COc1ccc(cc1)-n2c(C)c([N+]([O-])=O)c3ccc(O)cc23
InChI
1S/C16H14N2O4/c1-10-16(18(20)21)14-8-5-12(19)9-15(14)17(10)11-3-6-13(22-2)7-4-11/h3-9,19H,1-2H3
InChI key
VVZNWYXIOADGSW-UHFFFAOYSA-N
General description
ID-8 是双特异性酪氨酸磷酸化调节激酶 1A (DYRK1A) 的抑制剂。
Biochem/physiol Actions
ID-8 在体外维持小鼠胚胎干细胞 (ESC) 的自我更新和多潜能性。以稳定的速度刺激增殖（在添加 10 μg/ml 的无血清培养基中观察到）M 为期 30 天）。
在体外维持小鼠胚胎干细胞 (ESC) 的自我更新和多能性。
Still not finding the right product?
Explore all of our products under ID-8
存储类别
11 - Combustible Solids
wgk
WGK 3
A High-Throughput Screen Identifies DYRK1A inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation
Monteiro M B, et al.
Journal of the American Society of Nephrology, ASN-2018040392 (2018)
Yusuke Higuchi et al.
Current molecular pharmacology, 9(3), 272-279 (2015-05-27)
Despite their high degree of identity and even higher homology, the two Kat3 transcriptional coactivators, CBP and p300, have distinct functions, particularly within the Wnt/β-catenin signaling cascade. ICG-001, by directly binding to CBP but not p300, inhibits CBP/β-catenin transcription and
Stefan Hindel et al.
PloS one, 10(6), e0128060-e0128060 (2015-06-11)
The purpose of our study was to validate perfusion quantification in a low-perfused tissue by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with shared k-space sampling using a blood pool contrast agent. Perfusion measurements were performed in a total of seven
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| I1786-5MG | 04061833066089 |
| I1786-25MG | 04061833066072 |