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Merck
CN

I1896

Sigma-Aldrich

白介素-13 来源于小鼠

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

别名:

IL-13

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关于此项目

MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.32
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生物来源

mouse

质量水平

重组

expressed in E. coli

方案

≥97% (SDS-PAGE)

表单

lyophilized powder

效能

1-10 ng/mL EC50

分子量

11.5 kDa (predicted; 9 kDa under reducing conditions)

包装

pkg of 5 μg

技术

cell culture | mammalian: suitable

杂质

endotoxin, tested

UniProt登记号

储存温度

−20°C

基因信息

mouse ... Il13(16163)

生化/生理作用

白细胞介素-13是由小鼠和人类中活化的Th2细胞产生的多效性细胞因子。IL-13主要分泌为132个氨基酸的未糖基化蛋白,分子量为10,000道尔顿。对小鼠IL-13基因的4.3 kb DNA片段进行测序,并以映射11号染色体的单拷贝形式出现。在人类中,IL-13基因的4.6 kb DNA片段以单拷贝形式出现,并映射到5号染色体。IL-13诱导B细胞增殖,还诱导IgE转换。使用人红白血病细胞系TF-1在培养物中检测人和小鼠IL-13产品的增殖活性。

外形

从含有50 μg牛血清白蛋白(BSA)/1 μg细胞因子的磷酸盐缓冲盐水(PBS)(pH值7.4)的0.2 μm过滤溶液中冻干

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

常规特殊物品
低风险生物材料
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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The Journal of biological chemistry, 290(20), 12858-12867 (2015-04-04)
Restoration of the antigen (Ag)-specific immune tolerance in an allergic environment is refractory. B cells are involved in immune regulation. Whether B cells facilitate the generation of Ag-specific immune tolerance in an allergic environment requires further investigation. This paper aims
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The leukotrienes (LTs) enhance allergen- and interleukin (IL)-13-dependent allergic lung inflammatory disease. However, the precise requirement of LTs and the mechanism by which they elicit allergic lung responses remain uncertain. To clarify the involvement of LTs in respiratory allergen- and
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Continual efferocytic clearance of apoptotic cells (ACs) by macrophages prevents necrosis and promotes injury resolution. How continual efferocytosis is promoted is not clear. Here, we show that the process is optimized by linking the metabolism of engulfed cargo from initial
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Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.

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