生物来源
mouse
质量水平
重组
expressed in E. coli
方案
≥97% (SDS-PAGE)
表单
lyophilized powder
效能
1-10 ng/mL EC50
分子量
11.5 kDa (predicted; 9 kDa under reducing conditions)
包装
pkg of 5 μg
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
mouse ... Il13(16163)
生化/生理作用
白细胞介素-13是由小鼠和人类中活化的Th2细胞产生的多效性细胞因子。IL-13主要分泌为132个氨基酸的未糖基化蛋白,分子量为10,000道尔顿。对小鼠IL-13基因的4.3 kb DNA片段进行测序,并以映射11号染色体的单拷贝形式出现。在人类中,IL-13基因的4.6 kb DNA片段以单拷贝形式出现,并映射到5号染色体。IL-13诱导B细胞增殖,还诱导IgE转换。使用人红白血病细胞系TF-1在培养物中检测人和小鼠IL-13产品的增殖活性。
外形
从含有50 μg牛血清白蛋白(BSA)/1 μg细胞因子的磷酸盐缓冲盐水(PBS)(pH值7.4)的0.2 μm过滤溶液中冻干
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
常规特殊物品
低风险生物材料
此项目有
Luke Hatchwell et al.
Thorax, 70(9), 854-861 (2015-06-26)
Asthma exacerbations represent a significant disease burden and are commonly caused by rhinovirus (RV), which is sensed by Toll-like receptors (TLR) such as TLR7. Some asthmatics have impaired interferon (IFN) responses to RV, but the underlying mechanisms of this clinically
Gui Yang et al.
The Journal of biological chemistry, 290(20), 12858-12867 (2015-04-04)
Restoration of the antigen (Ag)-specific immune tolerance in an allergic environment is refractory. B cells are involved in immune regulation. Whether B cells facilitate the generation of Ag-specific immune tolerance in an allergic environment requires further investigation. This paper aims
Kihyuk Shin et al.
Clinical and experimental medicine, 15(3), 233-244 (2014-06-14)
The leukotrienes (LTs) enhance allergen- and interleukin (IL)-13-dependent allergic lung inflammatory disease. However, the precise requirement of LTs and the mechanism by which they elicit allergic lung responses remain uncertain. To clarify the involvement of LTs in respiratory allergen- and
Arif Yurdagul et al.
Cell metabolism, 31(3), 518-533 (2020-02-01)
Continual efferocytic clearance of apoptotic cells (ACs) by macrophages prevents necrosis and promotes injury resolution. How continual efferocytosis is promoted is not clear. Here, we show that the process is optimized by linking the metabolism of engulfed cargo from initial
C Abrial et al.
British journal of pharmacology, 172(17), 4319-4330 (2015-06-05)
15-Lipoxygenase (15-LOX) activity is associated with inflammation and immune regulation. The objectives of the present study were to investigate the expression of 15-LOX-1 and 15-LOX-2 and evaluate the enzymes' roles in the polarization of human lung macrophages (LMs) in response
商品
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持