产品名称
白介素-1β 来源于大鼠, IL-1β, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
biological source
rat
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE and HPLC)
form
lyophilized powder
potency
0.01-0.1 ng/mL ED50/EC50
mol wt
17.3 kDa
packaging
pkg of 10 and 50 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
rat ... Il1b(24494)
Analysis Note
使用鼠D10S细胞在细胞增殖测定中对生物活性进行检测。
General description
白细胞介素-1(IL-1),最初称为淋巴细胞活化因子(LAF),可激活T细胞和淋巴细胞,从而使其进一步增殖并分泌白细胞介素-2。1 IL-1主要从受刺激的巨噬细胞和单核细胞中释放出来,但也可从其他几种细胞中释放出来,2 并被认为在炎症和免疫反应中起关键作用。3 IL-1的其他同义词包括:内源性热原(EP)、促有丝分裂蛋白(MP)、Helper Peak-1(HP-1)、T细胞替代因子III(TRF III或TRFH)、B细胞活化因子(BAF)、以及B细胞分化因子(BDF)。4 两种密切相关的试剂,白细胞介素-1α (IL-1α )和白细胞介素-1β(IL-1β)可结合相同的细胞表面受体,并引起几乎相同的生物反应,但它们的氨基酸序列中仅具有25%的同源性。重组大鼠IL-1β是一种含有153个氨基酸残基的,大小为17.3kDa的蛋白质。
Physical form
从0.2 μm过滤的缓冲溶液中冻干。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Wei Zhou et al.
Journal of neurophysiology, 117(6), 2282-2291 (2017-03-17)
Excessive inflammation including IL-1β-initiated signaling is among the earlies reactions that can cause neuronal damage following spinal cord injury (SCI). It has been suggested that microRNAs may participate in stem cell repair to facilitate functional recovery following SCI. In this
商品
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
相关内容
Datasheet
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