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I2411

Isocitrate Dehydrogenase 1 (NADP+) human

Name: Isocitrate Dehydrogenase 1 (NADP+) human
Brand: SIGMA

recombinant, expressed in Sf9 cells, ≥90% (SDS-PAGE)

别名:

IDH1, Isocitrate Dehydrogenase Cytoplasmic

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关于此项目

化学文摘社编号:

9028-48-2

UNSPSC Code:

12352204

NACRES:

NA.54

EC 号:

1.1.1.42 (BRENDA, IUBMB)

Assay:

≥90% (SDS-PAGE)

Recombinant:

expressed in Sf9 cells

Concentration:

≥0.30 mg/mL protein (Bradford)

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属性

recombinant

expressed in Sf9 cells

Quality Segment

200

assay

≥90% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

47.6 kDa

concentration

≥0.30 mg/mL protein (Bradford)

NCBI accession no.

NM_005896

relevant disease(s)

cancer (lung)

shipped in

dry ice

storage temp.

−70°C

说明

General description

Human Isocitrate Dehydrogenase (IDH1), also known as oxalosuccinate decarboxylase, full length [amino acids 1-414 (end)] with C-terminal FLAG-tag, expressed in Sf9 cells via a baculovirus expression system.

Application

Human Isocitrate Dehydrogenase (IDH1) is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. It may be useful as a biomarker for diagnosis and prognosis prediction of non-small cell lung cancer .

Biochem/physiol Actions

Human Isocitrate Dehydrogenase (IDH1), also known as oxalosuccinate decarboxylase, is a full length amino acid with a C-terminal FLAG-tag and is expressed in Sf9 cells via a baculovirus expression system. IDH1 expression has been correlated with poor survival of non-small cell lung cancer. IDH1 promotes tumor growth .

Physical form

Solution in 45 mM Tris-HCl, 124 mM NaCl, 2.4 mM KCl, 90 μg/ml FLAG peptide, 3 mM DTT, and 10% glycerol at pH 8.0.

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c