I2764
ML-7
≥98% (TLC), myosin light chain kinase inhibitor, powder
别名:
1-（5-碘萘-1-磺酰基）-1H - 六氢-1，4-二氮杂卓 盐酸盐
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关于此项目
经验公式（希尔记法）:
C15H17IN2O2S · HCl
化学文摘社编号:
分子量:
452.74
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
ML-7, powder
方案
≥98% (TLC)
质量水平
表单
powder
颜色
white
溶解性
ethanol: water (1:1): 10 mg/mL, clear, colorless to faintly yellow
储存温度
−20°C
SMILES字符串
Cl.Ic1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3
InChI
1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
InChI key
KDDALCDYHZIZMH-UHFFFAOYSA-N
基因信息
human ... MYLK(4638), MYLK2(85366)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
M Makishima et al.
FEBS letters, 287(1-2), 175-177 (1991-08-05)
Inhibitors of myosin light chain kinase, 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-9) and 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), induced Nitroblue tetrazolium reducing activity, lysozyme activity and morphological maturation of human monoblastic U937, THP-1 and promyelocytic HL-60 cells, but not of erythroblastic K562 cells. However, three
Ziad Al Nabhani et al.
Inflammatory bowel diseases, 23(7), 1109-1119 (2017-05-19)
Crohn's disease (CD) pathogenesis is multifactorial involving genetic and environmental factors. Loss of function mutations in the nucleotide oligomerization domain 2 (NOD2) gene are the main genetic risk factor for CD. Like patients with CD, Nod2 mice are characterized by
Zasp/Cypher internal ZM-motif containing fragments are sufficient to co-localize with alpha-actinin?Analysis of patient mutations
Klaavuniemi T and Ylanne J
Experimental Cell Research, 312(8), 1299-1311 (2006)
Inhibition of myosin light chain kinase can be targeted for the development of new therapies against herpes simplex virus type-1 infection
Antoine TE and Shukla D
Antiviral Therapy, 19, 15-29 (2014)
Kristopher E Kubow et al.
Scientific reports, 7(1), 14380-14380 (2017-11-01)
Contact guidance-cell polarization by anisotropic substrate features-is integral to numerous physiological processes; however the complexities of its regulation are only beginning to be discovered. In particular, cells polarize to anisotropic features under non-muscle myosin II (MII) inhibition, despite MII ordinarily
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