I3159
IMD-0354
≥98% (HPLC), solid
别名:
N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C15H8ClF6NO2
化学文摘社编号:
分子量:
383.67
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)
SMILES string
Oc1ccc(Cl)cc1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F
InChI key
CHILCFMQWMQVAL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
solubility
DMSO: >20 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
Application
IMD-0354 has been used to study the effect of NF-κB (nuclear factor) inhibition on differentially expressed in chondrocytes 2. It has also been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts.
Biochem/physiol Actions
IMD-0354 acts as an inhibitor by inhibiting the phosphorylation of the NF-κB (nuclear factor) and its translocation into the nucleus. It blocks IκBα phosphorylation (IC50 ~ 250 nM). Cardioprotectant, that reduces IL-1β and MCP-1 production (IC50 < 1 μM) in cardiomyocytes. IMD-0354 affects angiogenesis, which has been observed in human umbilical vein endothelial cells. It prevents tube formation and migration of the cells. In vivo studies also prove that IMD-0354 inhibits retinal vessel growth. IMD-0354 also acts as an inhibitor of Aquaporin 4 (AQP4) inhibitor (IC50 0.2μM) with no inhibitory potency to IKK-β. [4]
Packaging
Light sensitive. Packaged under nitrogen.
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Zhen-Yu Ma et al.
Biochemical and biophysical research communications, 471(4), 576-581 (2016-02-14)
Activated fibroblasts continue to proliferate at injury sites, leading to progressive muscular fibrosis in Duchenne muscular dystrophy (DMD). TGF-β1 is a dominant profibrotic mediator thought to play a critical role in muscle fibrosis; however, the implicated mechanisms are not fully
Investigating mechanisms of angiogenesis in health and disease using zebrafish models, 24-25 (2018)
Cecilia S Vieira et al.
Frontiers in physiology, 9, 1189-1189 (2018-09-21)
Rhodnius prolixus is an insect vector of Trypanosoma cruzi, the causative agent of Chagas disease in Latin America. Nuclear factor-κB (NF-κB) transcription factors (TF) are conserved components of the innate immune system in several multicellular organisms including insects. The drug
DEC2 Blocks the Effect of the ARNTL2/NPAS2 Dimer on the Expression of PER3 and DBP
Olkkonen J, et al.
Journal of circadian rhythms, 15 (2017)
Solbi Kim et al.
Scientific reports, 9(1), 10003-10003 (2019-07-12)
Elevated expression of transmembrane serine protease 4 (TMPRSS4) correlates with poor prognosis in non-small cell lung cancer, gastric cancer, colorectal cancer, prostate cancer, and other cancer patients. Previously, we demonstrated that TMPRSS4 mediates tumor cell invasion, migration, proliferation, and metastasis.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持