I3650
白细胞介素4 来源于大鼠
recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE)
别名:
rIL-4, IL-4
产品名称
白细胞介素4 来源于大鼠, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE)
biological source
rat
recombinant
expressed in E. coli
assay
≥97% (SDS-PAGE)
form
lyophilized powder
mol wt
predicted mol wt 13.5 kDa
packaging
pkg of 5 μg
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
rat ... Il4(287287)
Analysis Note
通过刺激大鼠脾细胞增殖的能力来测量重组大鼠IL-4的生物活性。
Biochem/physiol Actions
淋巴因子对免疫活性细胞的生长和分化具有明显的影响，抑制 VEGF和bFGF诱导的血管生成。
白介素-4是对免疫活性细胞的生长和分化具有明显的影响的淋巴因子。IL-4又称B细胞刺激因子-1（BSF-1）、T细胞生长因子-2（TCGF-2）和肥大细胞生长因子-2（MCGF-2）。抑制VEGF和bFGF诱导的血管生成。 IL-4是由活化的T细胞亚群释放的复合糖蛋白。人和小鼠 IL-4 具有50％的氨基酸序列同源性，但它们的生物学作用是物种特异性的。
白介素-4淋巴因子对免疫活性细胞的生长和分化具有明显的影响，抑制 VEGF和bFGF诱导的血管生成。人和小鼠 IL-4 具有50％的氨基酸序列一致性，但它们的生物学作用是物种特异性的。
Physical form
从含有0.25 mg牛血清白蛋白的磷酸盐缓冲盐水中经0.2 μm滤膜过滤的溶液中冻干。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Robert Nunan et al.
Glia, 62(8), 1313-1327 (2014-05-08)
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In order to modulate microglial phenotypes in vivo, M1 microglia were depleted by administration of gadolinium chloride and the expression of M2 microglia was induced by IL-4 administration in an animal model of sepsis to better characterize the role of
Jeremy A Daniel et al.
The Journal of cell biology, 183(5), 777-783 (2008-12-03)
Cellular responses to both physiological and pathological DNA double-strand breaks are initiated through activation of the evolutionarily conserved ataxia telangiectasia mutated (ATM) kinase. Upon DNA damage, an activation mechanism involving autophosphorylation has been reported to allow ATM to phosphorylate downstream
Mingming Zhang et al.
PloS one, 9(10), e109146-e109146 (2014-10-03)
It has been shown that Faecalibacterium prausnitzii (F. prausnitzii), one of the dominant intestinal bacterial flora, may protect colonic mucosa against the development of inflammation and subsequent inflammatory bowel disease (IBD), with the underlying mechanisms being unclear. The impacts of
Rebecca Winkelmann et al.
PloS one, 9(5), e97953-e97953 (2014-05-31)
Maturation as well as antigen-dependent activation of B cells is accompanied by alternating phases of proliferation and quiescence. We and others have previously shown that Krüppel-like factor 2 (KLF2), a regulator of T cell quiescence and migration, is upregulated in
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