I3766
异甘草素
powder
别名:
(E)-1-（2,4-二羟基苯基）-3-（4-羟基苯基）-2-丙烯-1-酮, 4,2′,4′-三羟基查尔酮
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关于此项目
经验公式（希尔记法）:
C15H12O4
化学文摘社编号:
分子量:
256.25
UNSPSC Code:
41106305
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1914296
产品名称
异甘草素, powder
InChI key
DXDRHHKMWQZJHT-FPYGCLRLSA-N
SMILES string
Oc1ccc(cc1)\C=C\C(=O)c2ccc(O)cc2O
InChI
1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+
form
powder
color
yellow to orange
solubility
H2O: <0.1 mg/mL
methanol: 10 mg/mL
DMSO: 20 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
rat ... Alox5(25290)
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Application
异甘草素已被用于：
- 作为斑马鱼胚胎中的骨形态发生蛋白（BMP）激动剂
- 作为斑马鱼胚胎中的鸟苷酸环化酶激活剂
- 用于测试其对Epstein-Barr病毒相关胃癌的抗肿瘤和抗病毒作用
Biochem/physiol Actions
异甘草素是一种可溶性鸟苷酸环化酶激活剂，具有抗肿瘤活性。它还具有抗氧化、抗血小板和雌激素特性。
Disclaimer
光敏性、吸湿性
Features and Benefits
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
General description
异甘草素是一种芳香族酮，属于查耳酮化合物类。它来源于甘草，是药品和食品中的一种成分。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
M Tawata et al.
European journal of pharmacology, 212(1), 87-92 (1992-02-25)
The mechanism was studied by which isoliquiritigenin, a new aldose reductase inhibitor purified from licorice (Glycyrrhizae radix), inhibits platelet aggregation. This new agent significantly inhibited the phosphorylation of 40,000- and 20,000-dalton proteins, and inhibited the formation of 12 (S)-hydroxy-5,8,10-heptadecatrienoic acid
Kai-Lee Wang et al.
Expert opinion on therapeutic targets, 17(4), 337-349 (2013-01-19)
Isoliquiritigenin (ISL) is a natural phenolic compound extracted from licorice. Previous studies have shown that ISL is a potent antioxidant with anti-inflammatory and antitumor activities. The anti-invasive activity of ISL was still unclear. The actual causes of death for most
S Yamamoto et al.
Carcinogenesis, 12(2), 317-323 (1991-02-01)
A topical application of a chalcone derivative, 4,2',4'-trihydroxychalcone (isoliquiritigenin) inhibited epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. inflammation, caused by a topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mice. In addition, isoliquiritigenin potently inhibited 7,12-dimethylbenz[alpha]anthracene (DMBA)-initiated and
Lei Yang et al.
Food chemistry, 138(1), 173-179 (2012-12-26)
An ionic liquid-based ultrasonic-assisted extraction (ILUAE) method had been used for the effective extraction of isoliquiritigenin (IQ), liquiritin (LQ) and glycyrrhizic acid (GA) from licorice. The ionic liquids with different cations and anions were investigated in this work and 0.5
Xuan Yuan et al.
Recent patents on anti-cancer drug discovery, 8(2), 191-199 (2012-09-12)
Isoliquiritigenin (ISL), a licorice chalconoid, is a bioactive agent with chemopreventive potential that has been patented for tumor treatment in China. This study investigated the mechanisms of ISL-induced apoptosis in ovarian carcinoma SKOV-3 cells. Cell viability was evaluated using a
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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