I3766
异甘草素
powder
别名:
(E)-1-（2,4-二羟基苯基）-3-（4-羟基苯基）-2-丙烯-1-酮, 4,2′,4′-三羟基查尔酮
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关于此项目
经验公式（希尔记法）:
C15H12O4
化学文摘社编号:
分子量:
256.25
UNSPSC Code:
41106305
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1914296
Form:
powder
Quality level:
form
powder
Quality Level
color
yellow to orange
solubility
H2O: <0.1 mg/mL, methanol: 10 mg/mL, DMSO: 20 mg/mL
storage temp.
2-8°C
SMILES string
Oc1ccc(cc1)\C=C\C(=O)c2ccc(O)cc2O
InChI
1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+
InChI key
DXDRHHKMWQZJHT-FPYGCLRLSA-N
Gene Information
rat ... Alox5(25290)
General description
异甘草素是一种芳香族酮，属于查耳酮化合物类。它来源于甘草，是药品和食品中的一种成分。
Application
异甘草素已被用于：
- 作为斑马鱼胚胎中的骨形态发生蛋白（BMP）激动剂
- 作为斑马鱼胚胎中的鸟苷酸环化酶激活剂
- 用于测试其对Epstein-Barr病毒相关胃癌的抗肿瘤和抗病毒作用
Biochem/physiol Actions
异甘草素是一种可溶性鸟苷酸环化酶激活剂，具有抗肿瘤活性。它还具有抗氧化、抗血小板和雌激素特性。
Features and Benefits
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
Disclaimer
光敏性、吸湿性
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta.
S M Yu et al.
British journal of pharmacology, 114(8), 1587-1594 (1995-04-01)
1. The vasorelaxant activity of isoliquiritigenin, isolated from Dalbergia odorifera T, was investigated in the phenylephrine-precontracted rat aorta by measuring tension, guanylate and adenylate cyclase activities, guanosine 3':5'-cyclic monophosphate (cyclic GMP) and adenosine 3':5'-cyclic monophosphate (cyclic AMP) levels. 2. Isoliquiritigenin
Small molecule modifier screen for kit-dependent functions in zebrafish embryonic melanocytes
Hultman KA, et al.
Zebrafish, 5(4), 279-287 (2008)
Suengmok Cho et al.
Biochemical and biophysical research communications, 413(4), 637-642 (2011-09-29)
Isoliquiritigenin (ILTG) is a chalcone compound and has valuable pharmacological properties such as antioxidant, anti-inflammatory, anticancer, and antiallergic activities. Recently, the anxiolytic effect of ILTG has been reported; however, its action mechanism and hypnotic activity have not yet been demonstrated.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| I3766-10MG | 04061833856338 |