I3766
异甘草素
powder
别名:
(E)-1-（2,4-二羟基苯基）-3-（4-羟基苯基）-2-丙烯-1-酮, 4,2′,4′-三羟基查尔酮
表单
powder
质量水平
颜色
yellow to orange
溶解性
H2O: <0.1 mg/mL
methanol: 10 mg/mL
DMSO: 20 mg/mL
储存温度
2-8°C
SMILES字符串
Oc1ccc(cc1)\C=C\C(=O)c2ccc(O)cc2O
InChI
1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+
InChI key
DXDRHHKMWQZJHT-FPYGCLRLSA-N
基因信息
rat ... Alox5(25290)
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一般描述
异甘草素是一种芳香族酮，属于查耳酮化合物类。它来源于甘草，是药品和食品中的一种成分。
应用
异甘草素已被用于：
- 作为斑马鱼胚胎中的骨形态发生蛋白（BMP）激动剂
- 作为斑马鱼胚胎中的鸟苷酸环化酶激活剂
- 用于测试其对Epstein-Barr病毒相关胃癌的抗肿瘤和抗病毒作用
生化/生理作用
异甘草素是一种可溶性鸟苷酸环化酶激活剂，具有抗肿瘤活性。它还具有抗氧化、抗血小板和雌激素特性。
特点和优势
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
免责声明
光敏性、吸湿性
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Wdr68 mediates dorsal and ventral patterning events for craniofacial development
Alvarado E, et al.
PLoS ONE, 11(11), e0166984-e0166984 (2016)
Xuan Yuan et al.
Recent patents on anti-cancer drug discovery, 8(2), 191-199 (2012-09-12)
Isoliquiritigenin (ISL), a licorice chalconoid, is a bioactive agent with chemopreventive potential that has been patented for tumor treatment in China. This study investigated the mechanisms of ISL-induced apoptosis in ovarian carcinoma SKOV-3 cells. Cell viability was evaluated using a
Lei Yang et al.
Food chemistry, 138(1), 173-179 (2012-12-26)
An ionic liquid-based ultrasonic-assisted extraction (ILUAE) method had been used for the effective extraction of isoliquiritigenin (IQ), liquiritin (LQ) and glycyrrhizic acid (GA) from licorice. The ionic liquids with different cations and anions were investigated in this work and 0.5
S Yamamoto et al.
Carcinogenesis, 12(2), 317-323 (1991-02-01)
A topical application of a chalcone derivative, 4,2',4'-trihydroxychalcone (isoliquiritigenin) inhibited epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. inflammation, caused by a topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mice. In addition, isoliquiritigenin potently inhibited 7,12-dimethylbenz[alpha]anthracene (DMBA)-initiated and
M Tawata et al.
European journal of pharmacology, 212(1), 87-92 (1992-02-25)
The mechanism was studied by which isoliquiritigenin, a new aldose reductase inhibitor purified from licorice (Glycyrrhizae radix), inhibits platelet aggregation. This new agent significantly inhibited the phosphorylation of 40,000- and 20,000-dalton proteins, and inhibited the formation of 12 (S)-hydroxy-5,8,10-heptadecatrienoic acid
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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