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Merck
CN

I3901

Sigma-Aldrich

白介素1α 来源于大鼠

IL-1α, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

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别名:
rIL-1α, IL-1α, 淋巴细胞激活因子
MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.77

生物来源

rat

质量水平

重组

expressed in E. coli

检测方案

≥97% (SDS-PAGE)

形式

lyophilized powder

效能

1-10 pg/mL EC50

质量

endotoxin tested

分子量

~18 kDa

包装

pkg of 5 μg

技术

cell culture | mammalian: suitable

杂质

≤0.1 EU/μg

UniProt登记号

储存温度

−20°C

基因信息

rat ... Il1a(24493)

生化/生理作用

白介素-1(IL-1),最初称为淋巴细胞激活因子(LA F),可激活T细胞和淋巴细胞,然后增殖并分泌白介素-2(L-2)。使用鼠细胞系D10S在培养物中检测人IL-1α的增殖活性。

外形

从含有0.25 mg牛血清白蛋白的0.2 μm过滤磷酸盐缓冲盐水中冻干。

分析说明

通过使用小鼠辅助T细胞系D10.G4.1刺激细胞增殖的能力来测量重组大鼠IL-1α的生物活性。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

含少量动物源组分生物产品
常规特殊物品

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Xuankang Wang et al.
Frontiers in neuroscience, 15, 768262-768262 (2021-11-20)
After spinal cord injury (SCI), reactive astrocytes can be classified into two distinctive phenotypes according to their different functions: neurotoxic (A1) astrocytes and neuroprotective (A2) astrocytes. Our previous studies proved that photobiomodulation (PBM) can promote motor function recovery and improve
T Nishida et al.
Journal of biochemistry, 105(3), 351-357 (1989-03-01)
A cDNA sequence coding for rat interleukin-1 alpha (IL-1 alpha) has been isolated from a cDNA library that was prepared with mRNA derived from LPS-stimulated rat peritoneal macrophages by using human IL-1 alpha cDNA as a probe. The rat cDNA
Xuankang Wang et al.
Journal of neuroinflammation, 18(1), 256-256 (2021-11-07)
Neurotoxic microglia and astrocytes begin to activate and participate in pathological processes after spinal cord injury (SCI), subsequently causing severe secondary damage and affecting tissue repair. We have previously reported that photobiomodulation (PBM) can promote functional recovery by reducing neuroinflammation
Sualyneth Galarza et al.
Advanced healthcare materials, 9(4), e1901419-e1901419 (2020-01-17)
Bioengineers have designed numerous instructive brain extracellular matrix (ECM) environments with tailored and tunable protein compositions and biomechanical properties in vitro to study astrocyte reactivity during trauma and inflammation. However, a major limitation of both protein-based and synthetic model microenvironments
Aybike Saglam et al.
Glia, 69(4), 1022-1036 (2020-12-15)
Astrocytes are key players in CNS neuroinflammation and neuroregeneration that may help or hinder recovery, depending on the context of the injury. Although pro-inflammatory factors that promote astrocyte-mediated neurotoxicity have been shown to be secreted by reactive microglia, anti-inflammatory factors

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Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.

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